γδ T cells: a sparkling star for clinical immunotherapy
Human γδ T cells are unconventional lymphocytes that function in innate and adaptive immune responses and immunosurveillance. These cells show potent cytotoxicity against tumor cells in a major histocompatibility complex unrestricted manner and have recently gained considerable attention as a sparkl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2022-08-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/100366 |
| _version_ | 1817996618198155264 |
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| author | Jiamian Zheng Xuan Jiang Haotian Zhao Wandi Wang Xiuli Wu Zhenyi Jin |
| author_facet | Jiamian Zheng Xuan Jiang Haotian Zhao Wandi Wang Xiuli Wu Zhenyi Jin |
| author_sort | Jiamian Zheng |
| collection | DOAJ |
| description | Human γδ T cells are unconventional lymphocytes that function in innate and adaptive immune responses and immunosurveillance. These cells show potent cytotoxicity against tumor cells in a major histocompatibility complex unrestricted manner and have recently gained considerable attention as a sparkling star for clinical immunotherapy. Clinical immunotherapy trials with activated γδ T cells are tolerated well. However, clinical benefits are still unsatisfactory. Therefore, anti-tumor effects need to further increase the cytotoxicity of γδ T cells via several mechanisms, including the novel nitrogen-containing bisphosphonate products, adjuvant use with a bispecific antibody and chimeric antigen receptor, co-immunotherapy with γδ T cells plus immune checkpoint inhibitors, and adoptive immunotherapy with Vδ1 T cells and T cells engineered to express a defined γδ T cell receptor. Here, this article describes the crucial role of γδ T cells in anti-tumor immunity, concludes transduction strategies and summarizes the different development of novel approaches for clinical applications and cancer immunotherapy, which may be effective in overcoming current therapeutic limitations. |
| first_indexed | 2024-04-14T02:25:00Z |
| format | Article |
| id | doaj.art-0820d3e7f4424bffad039804ce9929df |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-04-14T02:25:00Z |
| publishDate | 2022-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-0820d3e7f4424bffad039804ce9929df2022-12-22T02:17:54ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552022-08-012454055710.37349/ei.2022.00066γδ T cells: a sparkling star for clinical immunotherapyJiamian Zheng0Xuan Jiang1Haotian Zhao2Wandi Wang3Xiuli Wu4https://orcid.org/0000-0002-5202-6515Zhenyi Jin5https://orcid.org/0000-0002-3812-3626Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaInstitute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaInstitute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaInstitute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaInstitute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaDepartment of Pathology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, ChinaHuman γδ T cells are unconventional lymphocytes that function in innate and adaptive immune responses and immunosurveillance. These cells show potent cytotoxicity against tumor cells in a major histocompatibility complex unrestricted manner and have recently gained considerable attention as a sparkling star for clinical immunotherapy. Clinical immunotherapy trials with activated γδ T cells are tolerated well. However, clinical benefits are still unsatisfactory. Therefore, anti-tumor effects need to further increase the cytotoxicity of γδ T cells via several mechanisms, including the novel nitrogen-containing bisphosphonate products, adjuvant use with a bispecific antibody and chimeric antigen receptor, co-immunotherapy with γδ T cells plus immune checkpoint inhibitors, and adoptive immunotherapy with Vδ1 T cells and T cells engineered to express a defined γδ T cell receptor. Here, this article describes the crucial role of γδ T cells in anti-tumor immunity, concludes transduction strategies and summarizes the different development of novel approaches for clinical applications and cancer immunotherapy, which may be effective in overcoming current therapeutic limitations.https://www.explorationpub.com/Journals/ei/Article/100366γδt cellimmunotherapyadoptive cell therapy |
| spellingShingle | Jiamian Zheng Xuan Jiang Haotian Zhao Wandi Wang Xiuli Wu Zhenyi Jin γδ T cells: a sparkling star for clinical immunotherapy Exploration of Immunology γδt cell immunotherapy adoptive cell therapy |
| title | γδ T cells: a sparkling star for clinical immunotherapy |
| title_full | γδ T cells: a sparkling star for clinical immunotherapy |
| title_fullStr | γδ T cells: a sparkling star for clinical immunotherapy |
| title_full_unstemmed | γδ T cells: a sparkling star for clinical immunotherapy |
| title_short | γδ T cells: a sparkling star for clinical immunotherapy |
| title_sort | γδ t cells a sparkling star for clinical immunotherapy |
| topic | γδt cell immunotherapy adoptive cell therapy |
| url | https://www.explorationpub.com/Journals/ei/Article/100366 |
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