Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer
Alginate/lignin is a synthetic polymer rich in biological activity and is of great interest. Alginate is extracted from seaweed and lignin is extracted from corn stalks and leaves. In this paper, antioxidant activities of alginate/lignin were evaluated, such as total antioxidant activity, reducing p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/13/5181 |
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| author | Nguyen Xuan Hoan Le Thi Hong Anh Hoang Thai Ha Dang Xuan Cuong |
| author_facet | Nguyen Xuan Hoan Le Thi Hong Anh Hoang Thai Ha Dang Xuan Cuong |
| author_sort | Nguyen Xuan Hoan |
| collection | DOAJ |
| description | Alginate/lignin is a synthetic polymer rich in biological activity and is of great interest. Alginate is extracted from seaweed and lignin is extracted from corn stalks and leaves. In this paper, antioxidant activities of alginate/lignin were evaluated, such as total antioxidant activity, reducing power activity, DPPH free radical scavenging activity, and α-glucosidase inhibition activity. Anticancer activity was evaluated in three cell lines (Hep G2, MCF-7, and NCI H460) and fibroblast. Physico-chemistry characteristics of alginate/lignin were determined through FTIR, DSC, SEM_EDS, SEM_EDS mapping, XRD, XRF, and <sup>1</sup>H-NMR. The acute toxicity of alginate/lignin was studied on <i>Swiss albino</i> mice. The results demonstrated that alginate/lignin possessed antioxidant activity, such as the total antioxidant activity, and reducing power activity, especially the α-glucosidase inhibition activity, and had no free radical scavenging activity. Alginate/lignin was not typical in cancer cell lines. Alginate/lignin existed in a thermally stable and regular spherical shape in the investigated thermal region. Six metals, three non-metals, and nineteen oxides were detected in alginate/lignin. Some specific functional groups of alginate and lignin did not exist in alginate/lignin crystal. Elements, such as C, O, Na, and S were popular in the alginate/lignin structure. LD<sub>0</sub> and LD<sub>100</sub> of alginate/lignin in mice were 3.91 g/kg and 9.77 g/kg, respectively. Alginate/lignin has potential for applications in pharmaceutical materials, functional foods, and supporting diabetes treatment. |
| first_indexed | 2024-03-11T01:32:53Z |
| format | Article |
| id | doaj.art-0820ea244d5a41809467bbc9e25fe45d |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T01:32:53Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0820ea244d5a41809467bbc9e25fe45d2023-11-18T17:09:24ZengMDPI AGMolecules1420-30492023-07-012813518110.3390/molecules28135181Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin PolymerNguyen Xuan Hoan0Le Thi Hong Anh1Hoang Thai Ha2Dang Xuan Cuong3Faculty of Biology and Environment, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh 70000, VietnamFaculty of Food Technology, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh 70000, VietnamFaculty of Food Technology, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh 70000, VietnamInnovation and Entrepreneurship Center, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh 70000, VietnamAlginate/lignin is a synthetic polymer rich in biological activity and is of great interest. Alginate is extracted from seaweed and lignin is extracted from corn stalks and leaves. In this paper, antioxidant activities of alginate/lignin were evaluated, such as total antioxidant activity, reducing power activity, DPPH free radical scavenging activity, and α-glucosidase inhibition activity. Anticancer activity was evaluated in three cell lines (Hep G2, MCF-7, and NCI H460) and fibroblast. Physico-chemistry characteristics of alginate/lignin were determined through FTIR, DSC, SEM_EDS, SEM_EDS mapping, XRD, XRF, and <sup>1</sup>H-NMR. The acute toxicity of alginate/lignin was studied on <i>Swiss albino</i> mice. The results demonstrated that alginate/lignin possessed antioxidant activity, such as the total antioxidant activity, and reducing power activity, especially the α-glucosidase inhibition activity, and had no free radical scavenging activity. Alginate/lignin was not typical in cancer cell lines. Alginate/lignin existed in a thermally stable and regular spherical shape in the investigated thermal region. Six metals, three non-metals, and nineteen oxides were detected in alginate/lignin. Some specific functional groups of alginate and lignin did not exist in alginate/lignin crystal. Elements, such as C, O, Na, and S were popular in the alginate/lignin structure. LD<sub>0</sub> and LD<sub>100</sub> of alginate/lignin in mice were 3.91 g/kg and 9.77 g/kg, respectively. Alginate/lignin has potential for applications in pharmaceutical materials, functional foods, and supporting diabetes treatment.https://www.mdpi.com/1420-3049/28/13/5181antioxidantanticancerglucosidasephysico-chemistry characteristicsacute toxicity |
| spellingShingle | Nguyen Xuan Hoan Le Thi Hong Anh Hoang Thai Ha Dang Xuan Cuong Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer Molecules antioxidant anticancer glucosidase physico-chemistry characteristics acute toxicity |
| title | Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer |
| title_full | Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer |
| title_fullStr | Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer |
| title_full_unstemmed | Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer |
| title_short | Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer |
| title_sort | antioxidant activities anticancer activity physico chemistry characteristics and acute toxicity of alginate lignin polymer |
| topic | antioxidant anticancer glucosidase physico-chemistry characteristics acute toxicity |
| url | https://www.mdpi.com/1420-3049/28/13/5181 |
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