Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer
Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | Urology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442019302670 |
| _version_ | 1819067895183835136 |
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| author | Cam Nguyen Stephen Leslie John Gross Nicholas Dietz Subodh M. Lele Gopi Sirineni |
| author_facet | Cam Nguyen Stephen Leslie John Gross Nicholas Dietz Subodh M. Lele Gopi Sirineni |
| author_sort | Cam Nguyen |
| collection | DOAJ |
| description | Penile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology. Keywords: Penile cancer, Anal cancer, Chemotherapy, Radiotherapy, HPV, p16 |
| first_indexed | 2024-12-21T16:25:31Z |
| format | Article |
| id | doaj.art-0822cab3577b4610ac3ec0638af3deef |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-12-21T16:25:31Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-0822cab3577b4610ac3ec0638af3deef2022-12-21T18:57:27ZengElsevierUrology Case Reports2214-44202019-11-0127Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancerCam Nguyen0Stephen Leslie1John Gross2Nicholas Dietz3Subodh M. Lele4Gopi Sirineni5Division of Radiation Oncology, Creighton University Medical Center, Omaha, NE, USA; Corresponding author. Division of Radiation Oncology, Creighton University Medical Center, 7500 Mercy Rd, Omaha, NE, 68124, USA.Department of Urology, Creighton University School of Medicine, Omaha, NE, USADepartment of Pathology, Creighton University Medical Center, Omaha, NE, USADepartment of Pathology, Creighton University Medical Center, Omaha, NE, USADepartment of Pathology, University of Nebraska Medical Center, Omaha, NE, USADepartment of Radiology, Creighton University Medical Center, Omaha, NE, USAPenile cancer is normally discovered in an early stage due to its visibility to the patient. This case report demonstrates a morbidly obese patient with a locally advanced penile cancer hidden by fatty tissue. Biopsy showed P16-positive tumor cells, which responded to concurrent chemo-radiotherapy with no evidence of disease at 24 months of follow-up. We also review the significance of p16-positive cell biology. Keywords: Penile cancer, Anal cancer, Chemotherapy, Radiotherapy, HPV, p16http://www.sciencedirect.com/science/article/pii/S2214442019302670 |
| spellingShingle | Cam Nguyen Stephen Leslie John Gross Nicholas Dietz Subodh M. Lele Gopi Sirineni Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer Urology Case Reports |
| title | Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer |
| title_full | Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer |
| title_fullStr | Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer |
| title_full_unstemmed | Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer |
| title_short | Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer |
| title_sort | penile cancer with positive nodes a case of hpv p16 positivity and its significance implication of data from head and neck cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2214442019302670 |
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