Enhanced Pentostatin Production in <i>Actinomadura</i> sp. by Combining ARTP Mutagenesis, Ribosome Engineering and Subsequent Fermentation Optimization

Enhanced Pentostatin Production in <i>Actinomadura</i> sp. by Combining ARTP Mutagenesis, Ribosome Engineering and Subsequent Fermentation Optimization

The special structure of pentostatin causes it to possess a wide spectrum of biological and pharmacological properties, and it has been extensively employed to treat malignant tumors and is the first-line treatment for hairy cell leukemia. Pentostatin is mainly distributed in several actinomycetes a...

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Bibliographic Details
Main Authors: Hongyu Zhang, Deguang Zhang, Ran Liu, Tingting Lou, Ruyue Tan, Suying Wang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Fermentation
Subjects:
<i>Actinomadura</i> sp.
pentostatin
atmospheric and room temperature plasma
ribosome engineering
Online Access:https://www.mdpi.com/2311-5637/9/4/398

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