Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis
Introduction: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increas...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/5123/9854_CE(Ra)_F(Sh)_PF1(AJAK)_PFA(Sh)_PFA2(AK)_PF2(PAG).pdf |
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| author | Sonia Gupta Manjunath SM Manveen kaur Jawanda Achla Bharti |
| author_facet | Sonia Gupta Manjunath SM Manveen kaur Jawanda Achla Bharti |
| author_sort | Sonia Gupta |
| collection | DOAJ |
| description | Introduction: Fibrinogen degradation products (FDPs) are the
products that are released from fibrin/fibrinogen. Recently, it
has been observed that these FDPs have been identified in the
plasma of OSMF patients. Areca nut being the major aetiological
agent for OSMF may play a role in the increased plasma levels
of FDPs in OSMF.
Aim: The aim of this study was to quantify the plasma FDPs
levels in the individuals with the habit of areca nut chewing with
and without OSMF.
Materials & Methods: Total of 95 subjects were included,35
subjects with the habit of areca nut chewing with OSMF, 30
with the habit of areca nut chewing without OSMF, 30 without
any habit of areca nut chewing without OSMF (control group).
Five ml of venous blood was withdrawn from all the subjects
and plasma FDP levels were estimated.
Results: Plasma FDPs were detected in all the subjects of
OSMF but could not be detected in other two groups. As the
clinical grades of OSMF increased, levels of plasma FDPs also
increased.
Conclusion: When plasma FDP increases, fibrin deposition
also increases. This strengthens the finding that these FDPs
may be an early indicator of the OSMF. |
| first_indexed | 2024-12-10T21:36:36Z |
| format | Article |
| id | doaj.art-0825be3189794b1e864995fad9cc8bba |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T21:36:36Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0825be3189794b1e864995fad9cc8bba2022-12-22T01:32:37ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811ZC27ZC3010.7860/JCDR/2014/9854.5123Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous FibrosisSonia Gupta0Manjunath SM1Manveen kaur Jawanda2Achla Bharti3Senior Lecturer, Department of Oral Pathology, Swami Devi Dyal Hospital & Dental College, Golpura, Barwala, India.Professor, Department of Oral Pathology, MMCDSR, Mullana, Ambala, India.Professor & HOD, Department of Oral Pathology, Laxmibai institute of Dental Sciences and Hospital , Patiala, India.Assistant Professor, Department of Oral Pathology, Govt Dental College, Rohtak, India.Introduction: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increased plasma levels of FDPs in OSMF. Aim: The aim of this study was to quantify the plasma FDPs levels in the individuals with the habit of areca nut chewing with and without OSMF. Materials & Methods: Total of 95 subjects were included,35 subjects with the habit of areca nut chewing with OSMF, 30 with the habit of areca nut chewing without OSMF, 30 without any habit of areca nut chewing without OSMF (control group). Five ml of venous blood was withdrawn from all the subjects and plasma FDP levels were estimated. Results: Plasma FDPs were detected in all the subjects of OSMF but could not be detected in other two groups. As the clinical grades of OSMF increased, levels of plasma FDPs also increased. Conclusion: When plasma FDP increases, fibrin deposition also increases. This strengthens the finding that these FDPs may be an early indicator of the OSMF.https://jcdr.net/articles/PDF/5123/9854_CE(Ra)_F(Sh)_PF1(AJAK)_PFA(Sh)_PFA2(AK)_PF2(PAG).pdfareca nutfdpsfibrinfibrinogenosmf |
| spellingShingle | Sonia Gupta Manjunath SM Manveen kaur Jawanda Achla Bharti Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis Journal of Clinical and Diagnostic Research areca nut fdps fibrin fibrinogen osmf |
| title | Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis |
| title_full | Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis |
| title_fullStr | Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis |
| title_full_unstemmed | Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis |
| title_short | Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis |
| title_sort | quantification of plasma fibrinogen degradation products in areca nut chewers with and without oral submucous fibrosis |
| topic | areca nut fdps fibrin fibrinogen osmf |
| url | https://jcdr.net/articles/PDF/5123/9854_CE(Ra)_F(Sh)_PF1(AJAK)_PFA(Sh)_PFA2(AK)_PF2(PAG).pdf |
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