High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer
Abstract Background Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a newly identified key kinase that regulate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Cancer Cell International |
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| Online Access: | http://link.springer.com/article/10.1186/s12935-019-0882-2 |
| _version_ | 1818442212974788608 |
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| author | Ling Yao Lei Wang Zhi-Gang Cao Xin Hu Zhi-Ming Shao |
| author_facet | Ling Yao Lei Wang Zhi-Gang Cao Xin Hu Zhi-Ming Shao |
| author_sort | Ling Yao |
| collection | DOAJ |
| description | Abstract Background Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a newly identified key kinase that regulates transcriptional reprogramming and cell proliferation. Here we show the prognostic value of PFKFB4 expression in patients with operable breast cancer. Methods PFKFB4 expression was evaluated by immunohistochemistry in surgical specimens retrospectively collected from 200 patients with histologically proven invasive ductal breast cancer. Kaplan–Meier survival analysis and Cox regression analysis were performed to assess the prognostic significance of PFKFB4 expression. Results Kaplan–Meier survival analysis revealed that breast cancer patients with high PFKFB4 expression demonstrated unfavorable disease-free survival (p = 0.008) and overall survival (p = 0.002). PFKFB4 had an hazard ratio (HR) of 7.38 (95% CI 1.69–32.3; p = 0.008) in univariate Cox analysis and retained prognostic power (HR 7.44, 95% CI 1.67–33.2; p = 0.009) when adjusted by tumor size, lymph node status, grade, estrogen receptor status, human epidermal growth factor receptor 2 status and subtype, which indicated PFKFB4 was an independent prognostic factor in breast cancer. Conclusions Together, our findings establish the prognostic value of metabolic enzyme PFKFB4 in patients with operable breast cancer. |
| first_indexed | 2024-12-14T18:40:34Z |
| format | Article |
| id | doaj.art-08265023df5340d7867e2f49c0b30d24 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T18:40:34Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-08265023df5340d7867e2f49c0b30d242022-12-21T22:51:29ZengBMCCancer Cell International1475-28672019-06-011911810.1186/s12935-019-0882-2High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancerLing Yao0Lei Wang1Zhi-Gang Cao2Xin Hu3Zhi-Ming Shao4Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan UniversityAbstract Background Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a newly identified key kinase that regulates transcriptional reprogramming and cell proliferation. Here we show the prognostic value of PFKFB4 expression in patients with operable breast cancer. Methods PFKFB4 expression was evaluated by immunohistochemistry in surgical specimens retrospectively collected from 200 patients with histologically proven invasive ductal breast cancer. Kaplan–Meier survival analysis and Cox regression analysis were performed to assess the prognostic significance of PFKFB4 expression. Results Kaplan–Meier survival analysis revealed that breast cancer patients with high PFKFB4 expression demonstrated unfavorable disease-free survival (p = 0.008) and overall survival (p = 0.002). PFKFB4 had an hazard ratio (HR) of 7.38 (95% CI 1.69–32.3; p = 0.008) in univariate Cox analysis and retained prognostic power (HR 7.44, 95% CI 1.67–33.2; p = 0.009) when adjusted by tumor size, lymph node status, grade, estrogen receptor status, human epidermal growth factor receptor 2 status and subtype, which indicated PFKFB4 was an independent prognostic factor in breast cancer. Conclusions Together, our findings establish the prognostic value of metabolic enzyme PFKFB4 in patients with operable breast cancer.http://link.springer.com/article/10.1186/s12935-019-0882-2PFKFB4Overall survivalDisease-free survivalBreast cancer |
| spellingShingle | Ling Yao Lei Wang Zhi-Gang Cao Xin Hu Zhi-Ming Shao High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer Cancer Cell International PFKFB4 Overall survival Disease-free survival Breast cancer |
| title | High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer |
| title_full | High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer |
| title_fullStr | High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer |
| title_full_unstemmed | High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer |
| title_short | High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer |
| title_sort | high expression of metabolic enzyme pfkfb4 is associated with poor prognosis of operable breast cancer |
| topic | PFKFB4 Overall survival Disease-free survival Breast cancer |
| url | http://link.springer.com/article/10.1186/s12935-019-0882-2 |
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