Genetic Susceptibility of the Host in Virus-Induced Diabetes
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be co...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/8/8/1133 |
| _version_ | 1827712266768744448 |
|---|---|
| author | Keiichiro Mine Yasunobu Yoshikai Hirokazu Takahashi Hitoe Mori Keizo Anzai Seiho Nagafuchi |
| author_facet | Keiichiro Mine Yasunobu Yoshikai Hirokazu Takahashi Hitoe Mori Keizo Anzai Seiho Nagafuchi |
| author_sort | Keiichiro Mine |
| collection | DOAJ |
| description | Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID. |
| first_indexed | 2024-03-10T18:10:41Z |
| format | Article |
| id | doaj.art-0828a2da3d374e96acb141e7d66a6e8d |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:10:41Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-0828a2da3d374e96acb141e7d66a6e8d2023-11-20T08:06:09ZengMDPI AGMicroorganisms2076-26072020-07-0188113310.3390/microorganisms8081133Genetic Susceptibility of the Host in Virus-Induced DiabetesKeiichiro Mine0Yasunobu Yoshikai1Hirokazu Takahashi2Hitoe Mori3Keizo Anzai4Seiho Nagafuchi5Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, JapanDivision of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDivision of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, JapanDivision of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, JapanDivision of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, JapanDivision of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, JapanEnteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.https://www.mdpi.com/2076-2607/8/8/1133diabetesvirussusceptibility genes |
| spellingShingle | Keiichiro Mine Yasunobu Yoshikai Hirokazu Takahashi Hitoe Mori Keizo Anzai Seiho Nagafuchi Genetic Susceptibility of the Host in Virus-Induced Diabetes Microorganisms diabetes virus susceptibility genes |
| title | Genetic Susceptibility of the Host in Virus-Induced Diabetes |
| title_full | Genetic Susceptibility of the Host in Virus-Induced Diabetes |
| title_fullStr | Genetic Susceptibility of the Host in Virus-Induced Diabetes |
| title_full_unstemmed | Genetic Susceptibility of the Host in Virus-Induced Diabetes |
| title_short | Genetic Susceptibility of the Host in Virus-Induced Diabetes |
| title_sort | genetic susceptibility of the host in virus induced diabetes |
| topic | diabetes virus susceptibility genes |
| url | https://www.mdpi.com/2076-2607/8/8/1133 |
| work_keys_str_mv | AT keiichiromine geneticsusceptibilityofthehostinvirusinduceddiabetes AT yasunobuyoshikai geneticsusceptibilityofthehostinvirusinduceddiabetes AT hirokazutakahashi geneticsusceptibilityofthehostinvirusinduceddiabetes AT hitoemori geneticsusceptibilityofthehostinvirusinduceddiabetes AT keizoanzai geneticsusceptibilityofthehostinvirusinduceddiabetes AT seihonagafuchi geneticsusceptibilityofthehostinvirusinduceddiabetes |