Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression
Renal fibrosis is a common progressive manifestation of chronic kidney disease. This phenomenon of self-repair in response to kidney damage seriously affects the normal filtration function of the kidney. Yet, there are no specific treatments for the condition, which marks fibrosis as an irreversible...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.986405/full |
| _version_ | 1798031915577507840 |
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| author | Jiayu Wang Jiayu Wang Jiaxing Li Jiaxing Li Xin Zhang Xin Zhang Min Zhang Min Zhang Min Zhang Xiaopeng Hu Xiaopeng Hu Hang Yin Hang Yin |
| author_facet | Jiayu Wang Jiayu Wang Jiaxing Li Jiaxing Li Xin Zhang Xin Zhang Min Zhang Min Zhang Min Zhang Xiaopeng Hu Xiaopeng Hu Hang Yin Hang Yin |
| author_sort | Jiayu Wang |
| collection | DOAJ |
| description | Renal fibrosis is a common progressive manifestation of chronic kidney disease. This phenomenon of self-repair in response to kidney damage seriously affects the normal filtration function of the kidney. Yet, there are no specific treatments for the condition, which marks fibrosis as an irreversible pathological sequela. As such, there is a pressing need to improve our understanding of how fibrosis develops at the cellular and molecular levels and explore specific targeted therapies for these pathogenic mechanisms. It is now generally accepted that renal fibrosis is a pathological transition mediated by extracellular matrix (ECM) deposition, abnormal activation of myofibroblasts, and epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells under the regulation of TGF-β. Histone deacetylases (HDACs) appear to play an essential role in promoting renal fibrosis through non-histone epigenetic modifications. In this review, we summarize the mechanisms of renal fibrosis and the signaling pathways that might be involved in HDACs in renal fibrosis, and the specific mechanisms of action of various HDAC inhibitors (HDACi) in the anti-fibrotic process to elucidate HDACi as a novel therapeutic tool to slow down the progression of renal fibrosis. |
| first_indexed | 2024-04-11T20:05:29Z |
| format | Article |
| id | doaj.art-082a57553a83437fb86a3a10548671ac |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T20:05:29Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-082a57553a83437fb86a3a10548671ac2022-12-22T04:05:20ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-09-01910.3389/fmolb.2022.986405986405Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progressionJiayu Wang0Jiayu Wang1Jiaxing Li2Jiaxing Li3Xin Zhang4Xin Zhang5Min Zhang6Min Zhang7Min Zhang8Xiaopeng Hu9Xiaopeng Hu10Hang Yin11Hang Yin12Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Research Ward, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, ChinaRenal fibrosis is a common progressive manifestation of chronic kidney disease. This phenomenon of self-repair in response to kidney damage seriously affects the normal filtration function of the kidney. Yet, there are no specific treatments for the condition, which marks fibrosis as an irreversible pathological sequela. As such, there is a pressing need to improve our understanding of how fibrosis develops at the cellular and molecular levels and explore specific targeted therapies for these pathogenic mechanisms. It is now generally accepted that renal fibrosis is a pathological transition mediated by extracellular matrix (ECM) deposition, abnormal activation of myofibroblasts, and epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells under the regulation of TGF-β. Histone deacetylases (HDACs) appear to play an essential role in promoting renal fibrosis through non-histone epigenetic modifications. In this review, we summarize the mechanisms of renal fibrosis and the signaling pathways that might be involved in HDACs in renal fibrosis, and the specific mechanisms of action of various HDAC inhibitors (HDACi) in the anti-fibrotic process to elucidate HDACi as a novel therapeutic tool to slow down the progression of renal fibrosis.https://www.frontiersin.org/articles/10.3389/fmolb.2022.986405/fullrenal fibrosisCKDHDACsHDAC inhibitorsTGF-βBMP-7 |
| spellingShingle | Jiayu Wang Jiayu Wang Jiaxing Li Jiaxing Li Xin Zhang Xin Zhang Min Zhang Min Zhang Min Zhang Xiaopeng Hu Xiaopeng Hu Hang Yin Hang Yin Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression Frontiers in Molecular Biosciences renal fibrosis CKD HDACs HDAC inhibitors TGF-β BMP-7 |
| title | Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| title_full | Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| title_fullStr | Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| title_full_unstemmed | Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| title_short | Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| title_sort | molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression |
| topic | renal fibrosis CKD HDACs HDAC inhibitors TGF-β BMP-7 |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.986405/full |
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