Analysis of Givinostat/ITF2357 Treatment in a Rat Model of Neonatal Hypoxic-Ischemic Brain Damage

Analysis of Givinostat/ITF2357 Treatment in a Rat Model of Neonatal Hypoxic-Ischemic Brain Damage

The histone deacetylase inhibitor (HDACi) Givinostat/ITF2357 provides neuroprotection in adult models of brain injury; however, its action after neonatal hypoxia-ischemia (HI) is still undefined. The aim of our study was to test the hypothesis that the mechanism of Givinostat is associated with the...

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Bibliographic Details
Main Authors: Paulina Pawelec, Joanna Sypecka, Teresa Zalewska, Malgorzata Ziemka-Nalecz
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
neonatal hypoxia-ischemia
HDAC
histone deacetylase inhibitor
givinostat/ITF2357
microglia
fractalkine/CX3CL1
Online Access:https://www.mdpi.com/1422-0067/23/15/8287

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