Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis
Background Psychiatric disorders, such as depression and anxiety, are commonly associated with epilepsy in the general population, but the relationship between psychiatric disorders and epilepsy among adults with intellectual disabilities is unclear. Aims To conduct a systematic review and meta-ana...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-05-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472421000557/type/journal_article |
| _version_ | 1811156981878095872 |
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| author | Basma Akrout Brizard Bharati Limbu Carolina Baeza-Velasco Shoumitro Deb |
| author_facet | Basma Akrout Brizard Bharati Limbu Carolina Baeza-Velasco Shoumitro Deb |
| author_sort | Basma Akrout Brizard |
| collection | DOAJ |
| description | Background
Psychiatric disorders, such as depression and anxiety, are commonly associated with epilepsy in the general population, but the relationship between psychiatric disorders and epilepsy among adults with intellectual disabilities is unclear.
Aims
To conduct a systematic review and meta-analysis to assess whether epilepsy is associated with an increased rate of psychiatric disorders in adults with intellectual disabilities.
Method
We included literature published between 1985 and 2020 from four databases, and hand-searched six relevant journals. We assessed risk of bias by using SIGN 50 and the Cochrane risk of bias tool. Several meta-analyses were carried out.
Results
We included 29 papers involving data on 9594 adults with intellectual disabilities, 3180 of whom had epilepsy and 6414 did not. Of the 11 controlled studies that compared the overall rate of psychiatric disorders between the epilepsy and non-epilepsy groups, seven did not show any significant inter-group difference. Meta-analysis was possible on pooled data from seven controlled studies, which did not show any significant inter-group difference in the overall rate of psychiatric disorders. The rates of psychotic disorders, depressive disorders and anxiety disorders were significantly higher in the non-epilepsy control groups compared with the epilepsy group, with effect sizes of 0.29, 0.47 and 0.58, respectively. Epilepsy-related factors did not show any definite association with psychiatric disorders.
Conclusions
It is difficult to pool data from such heterogeneous studies and draw any definitive conclusion because most studies lacked an appropriately matched control group, which will be required for future studies.
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| first_indexed | 2024-04-10T04:58:43Z |
| format | Article |
| id | doaj.art-082e49bceaa24cbe9887b53e61344a0e |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:58:43Z |
| publishDate | 2021-05-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-082e49bceaa24cbe9887b53e61344a0e2023-03-09T12:29:06ZengCambridge University PressBJPsych Open2056-47242021-05-01710.1192/bjo.2021.55Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysisBasma Akrout Brizard0https://orcid.org/0000-0003-4576-4824Bharati Limbu1Carolina Baeza-Velasco2Shoumitro Deb3https://orcid.org/0000-0002-1300-8103Université de Paris, Laboratory of Psychopathology and Health Processes, F-92100 Boulogne Billancourt, FranceDepartment of Brain Sciences, Faculty of Medicine, Imperial College London, UKLaboratory of Psychopathology and Health Processes, Université de Paris, France; and Department of Emergency Psychiatry and Acute Care, CHU Montpellier, FranceDivision of Psychiatry, Department of Brain Sciences, Faculty of Medicine, Imperial College London, UKBackground Psychiatric disorders, such as depression and anxiety, are commonly associated with epilepsy in the general population, but the relationship between psychiatric disorders and epilepsy among adults with intellectual disabilities is unclear. Aims To conduct a systematic review and meta-analysis to assess whether epilepsy is associated with an increased rate of psychiatric disorders in adults with intellectual disabilities. Method We included literature published between 1985 and 2020 from four databases, and hand-searched six relevant journals. We assessed risk of bias by using SIGN 50 and the Cochrane risk of bias tool. Several meta-analyses were carried out. Results We included 29 papers involving data on 9594 adults with intellectual disabilities, 3180 of whom had epilepsy and 6414 did not. Of the 11 controlled studies that compared the overall rate of psychiatric disorders between the epilepsy and non-epilepsy groups, seven did not show any significant inter-group difference. Meta-analysis was possible on pooled data from seven controlled studies, which did not show any significant inter-group difference in the overall rate of psychiatric disorders. The rates of psychotic disorders, depressive disorders and anxiety disorders were significantly higher in the non-epilepsy control groups compared with the epilepsy group, with effect sizes of 0.29, 0.47 and 0.58, respectively. Epilepsy-related factors did not show any definite association with psychiatric disorders. Conclusions It is difficult to pool data from such heterogeneous studies and draw any definitive conclusion because most studies lacked an appropriately matched control group, which will be required for future studies. https://www.cambridge.org/core/product/identifier/S2056472421000557/type/journal_articleIntellectual disabilitiesepilepsypsychiatric disorderssystematic reviewmeta-analysis |
| spellingShingle | Basma Akrout Brizard Bharati Limbu Carolina Baeza-Velasco Shoumitro Deb Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis BJPsych Open Intellectual disabilities epilepsy psychiatric disorders systematic review meta-analysis |
| title | Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis |
| title_full | Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis |
| title_fullStr | Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis |
| title_full_unstemmed | Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis |
| title_short | Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis |
| title_sort | association between epilepsy and psychiatric disorders in adults with intellectual disabilities systematic review and meta analysis |
| topic | Intellectual disabilities epilepsy psychiatric disorders systematic review meta-analysis |
| url | https://www.cambridge.org/core/product/identifier/S2056472421000557/type/journal_article |
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