An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy
As a type of regulated cell death (RCD), immunogenic cell death (ICD) can initiate the adaptive immune responses. Numerous reports highlight the capacity of ICD to alter the tumor immune microenvironment by releasing Damage-Associated Molecular Patterns (DAMP) or danger signals to boost the efficacy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1010787/full |
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| author | Xinghe Liao Xinghe Liao Hui Liu Zhe Zhang Zhe Zhang Jing Zhang Jing Zhang Chenyue Zhang Chenyue Zhang Weiwei Zhao Weiwei Zhao |
| author_facet | Xinghe Liao Xinghe Liao Hui Liu Zhe Zhang Zhe Zhang Jing Zhang Jing Zhang Chenyue Zhang Chenyue Zhang Weiwei Zhao Weiwei Zhao |
| author_sort | Xinghe Liao |
| collection | DOAJ |
| description | As a type of regulated cell death (RCD), immunogenic cell death (ICD) can initiate the adaptive immune responses. Numerous reports highlight the capacity of ICD to alter the tumor immune microenvironment by releasing Damage-Associated Molecular Patterns (DAMP) or danger signals to boost the efficacy of immunotherapy. Therefore, identification of the ICD-associated biomarkers is crucial for the prediction of ICD-induced immune responses. In this report, the consensus clustering technique was used to identify two subcategories (subtypes) linked to ICD. In comparison to the ICD-low subcategory, the ICD-high subcategory showed longer survival and more immune cell infiltration. Then, a novel ICD-associated prognostic model was developed and validated for predicting the survival of patients with breast invasive carcinomas (BRCA) and is linked to the tumor immune microenvironment. To conclude, a novel ICD-based BRCA classification scheme was designed. For individuals with BRCA, this categorization will be crucial for directing the assessment of prognosis and treatment. |
| first_indexed | 2024-04-13T18:37:38Z |
| format | Article |
| id | doaj.art-082fb15599ba45e4bc9b8ab667e1c13e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T18:37:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-082fb15599ba45e4bc9b8ab667e1c13e2022-12-22T02:34:50ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-10-011310.3389/fgene.2022.10107871010787An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapyXinghe Liao0Xinghe Liao1Hui Liu2Zhe Zhang3Zhe Zhang4Jing Zhang5Jing Zhang6Chenyue Zhang7Chenyue Zhang8Weiwei Zhao9Weiwei Zhao10Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaAs a type of regulated cell death (RCD), immunogenic cell death (ICD) can initiate the adaptive immune responses. Numerous reports highlight the capacity of ICD to alter the tumor immune microenvironment by releasing Damage-Associated Molecular Patterns (DAMP) or danger signals to boost the efficacy of immunotherapy. Therefore, identification of the ICD-associated biomarkers is crucial for the prediction of ICD-induced immune responses. In this report, the consensus clustering technique was used to identify two subcategories (subtypes) linked to ICD. In comparison to the ICD-low subcategory, the ICD-high subcategory showed longer survival and more immune cell infiltration. Then, a novel ICD-associated prognostic model was developed and validated for predicting the survival of patients with breast invasive carcinomas (BRCA) and is linked to the tumor immune microenvironment. To conclude, a novel ICD-based BRCA classification scheme was designed. For individuals with BRCA, this categorization will be crucial for directing the assessment of prognosis and treatment.https://www.frontiersin.org/articles/10.3389/fgene.2022.1010787/fullimmunogenic cell deathbreast invasive carcinomaprognosistumor immune microenvironmentbiomarker |
| spellingShingle | Xinghe Liao Xinghe Liao Hui Liu Zhe Zhang Zhe Zhang Jing Zhang Jing Zhang Chenyue Zhang Chenyue Zhang Weiwei Zhao Weiwei Zhao An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy Frontiers in Genetics immunogenic cell death breast invasive carcinoma prognosis tumor immune microenvironment biomarker |
| title | An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| title_full | An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| title_fullStr | An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| title_full_unstemmed | An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| title_short | An immunogenic cell death-associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| title_sort | immunogenic cell death associated classification predictions are important for breast invasive carcinoma prognosis and immunotherapy |
| topic | immunogenic cell death breast invasive carcinoma prognosis tumor immune microenvironment biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1010787/full |
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