Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response
The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21687-2 |
| _version_ | 1818735316653047808 |
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| author | Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa |
| author_facet | Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa |
| author_sort | Zdenek Andrysik |
| collection | DOAJ |
| description | The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer. |
| first_indexed | 2024-12-18T00:19:19Z |
| format | Article |
| id | doaj.art-08311375eed848a4a71efdc960482a8f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:19:19Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-08311375eed848a4a71efdc960482a8f2022-12-21T21:27:24ZengNature PortfolioNature Communications2041-17232021-03-0112111810.1038/s41467-021-21687-2Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic responseZdenek Andrysik0Heather Bender1Matthew D. Galbraith2Joaquin M. Espinosa3Department of Pharmacology, School of Medicine, University of Colorado Anschutz Medical CampusDepartment of Pharmacology, School of Medicine, University of Colorado Anschutz Medical CampusDepartment of Pharmacology, School of Medicine, University of Colorado Anschutz Medical CampusDepartment of Pharmacology, School of Medicine, University of Colorado Anschutz Medical CampusThe response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer.https://doi.org/10.1038/s41467-021-21687-2 |
| spellingShingle | Zdenek Andrysik Heather Bender Matthew D. Galbraith Joaquin M. Espinosa Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response Nature Communications |
| title | Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| title_full | Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| title_fullStr | Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| title_full_unstemmed | Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| title_short | Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| title_sort | multi omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response |
| url | https://doi.org/10.1038/s41467-021-21687-2 |
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