The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances
AIM: To investigate the clinical features of cystic fibrosis (CF) in adult patients with carbohydrate metabolic disturbances (CMD). Material and methods. CF was diagnosed on the basis of its clinical picture and a positive sweat test, and/or genetic study. Clinical, anthropometric, functional, micro...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2013-03-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31213 |
| _version_ | 1818524353869905920 |
|---|---|
| author | V A Samoĭlenko S A Krasovskiĭ Ia V Marchenkov S Iu Chikina G Iu Babadzhanova A B Nagornyĭ A G Chuchalin |
| author_facet | V A Samoĭlenko S A Krasovskiĭ Ia V Marchenkov S Iu Chikina G Iu Babadzhanova A B Nagornyĭ A G Chuchalin |
| author_sort | V A Samoĭlenko |
| collection | DOAJ |
| description | AIM: To investigate the clinical features of cystic fibrosis (CF) in adult patients with carbohydrate metabolic disturbances (CMD). Material and methods. CF was diagnosed on the basis of its clinical picture and a positive sweat test, and/or genetic study. Clinical, anthropometric, functional, microbiological data were compared with the results of imaging diagnosis in CF patients with and without CMD/RESULTS: The data of 350 patients were retrospectively analyzed. An oral glucose tolerance test was randomly performed in 154 CF patients without CMD. There was normal carbohydrate metabolism in 92 (59.7%) patients with CF, impaired glucose tolerance (IGT) in 44 (28.6%), CF-dependent diabetes mellitus (CFDDM) in 18 (11.7%). The latter had been previously diagnosed in 37 (10.6%) other patients with CF. Three groups of patients were formed: 1) 92 patients without CMD; 2) 44 with IGT, and 3) 55 with CFDDM. The patients with CFDDM had lower stature, weight, and lung function, significantly more common bronchiectases, a lower Staphylococcus aureus colonization with a tendency toward a higher Burkholderia cepacia colonization than those without CMD. As compared with the patients without CMD, those with this disorder were found to have a high rate of severe mutations; mild mutations were absent in the patients with CFDDM/CONCLUSION: CMD in CF is characterized by its high rates and latent course. The patients with CMD have retarded physical development, more pronounced morphofunctional disorders in the bronchopulmonary system, lower lung functional parameters, and more aggressive sputum microbial composition. |
| first_indexed | 2024-12-11T05:55:57Z |
| format | Article |
| id | doaj.art-083184dd730049dfabe6fa4f74e1eadc |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-11T05:55:57Z |
| publishDate | 2013-03-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-083184dd730049dfabe6fa4f74e1eadc2022-12-22T01:18:40Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422013-03-01853323728229The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbancesV A SamoĭlenkoS A KrasovskiĭIa V MarchenkovS Iu ChikinaG Iu BabadzhanovaA B NagornyĭA G ChuchalinAIM: To investigate the clinical features of cystic fibrosis (CF) in adult patients with carbohydrate metabolic disturbances (CMD). Material and methods. CF was diagnosed on the basis of its clinical picture and a positive sweat test, and/or genetic study. Clinical, anthropometric, functional, microbiological data were compared with the results of imaging diagnosis in CF patients with and without CMD/RESULTS: The data of 350 patients were retrospectively analyzed. An oral glucose tolerance test was randomly performed in 154 CF patients without CMD. There was normal carbohydrate metabolism in 92 (59.7%) patients with CF, impaired glucose tolerance (IGT) in 44 (28.6%), CF-dependent diabetes mellitus (CFDDM) in 18 (11.7%). The latter had been previously diagnosed in 37 (10.6%) other patients with CF. Three groups of patients were formed: 1) 92 patients without CMD; 2) 44 with IGT, and 3) 55 with CFDDM. The patients with CFDDM had lower stature, weight, and lung function, significantly more common bronchiectases, a lower Staphylococcus aureus colonization with a tendency toward a higher Burkholderia cepacia colonization than those without CMD. As compared with the patients without CMD, those with this disorder were found to have a high rate of severe mutations; mild mutations were absent in the patients with CFDDM/CONCLUSION: CMD in CF is characterized by its high rates and latent course. The patients with CMD have retarded physical development, more pronounced morphofunctional disorders in the bronchopulmonary system, lower lung functional parameters, and more aggressive sputum microbial composition.https://ter-arkhiv.ru/0040-3660/article/view/31213cystic fibrosisdiabetes mellituscarbohydrate metabolic disturbancescystic fibrosis-dependent diabetes mellitus |
| spellingShingle | V A Samoĭlenko S A Krasovskiĭ Ia V Marchenkov S Iu Chikina G Iu Babadzhanova A B Nagornyĭ A G Chuchalin The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances Терапевтический архив cystic fibrosis diabetes mellitus carbohydrate metabolic disturbances cystic fibrosis-dependent diabetes mellitus |
| title | The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| title_full | The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| title_fullStr | The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| title_full_unstemmed | The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| title_short | The clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| title_sort | clinical features of cystic fibrosis in adult patients with carbohydrate metabolic disturbances |
| topic | cystic fibrosis diabetes mellitus carbohydrate metabolic disturbances cystic fibrosis-dependent diabetes mellitus |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31213 |
| work_keys_str_mv | AT vasamoilenko theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT sakrasovskii theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT iavmarchenkov theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT siuchikina theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT giubabadzhanova theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT abnagornyi theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT agchuchalin theclinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT vasamoilenko clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT sakrasovskii clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT iavmarchenkov clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT siuchikina clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT giubabadzhanova clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT abnagornyi clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances AT agchuchalin clinicalfeaturesofcysticfibrosisinadultpatientswithcarbohydratemetabolicdisturbances |