The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives
In recent years, increasing attention has been paid to the role of neutrophils in cardiovascular (CV) disease (CVD) with evidence supporting their role in the initiation, progression, and rupture of atherosclerotic plaque. Although these cells have long been considered as terminally differentiated c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1169 |
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| author | Giacomo Buso Elisabetta Faggin Nathalie Rosenblatt-Velin Maxime Pellegrin Silvia Galliazzo Luca Calanca Marcello Rattazzi Lucia Mazzolai |
| author_facet | Giacomo Buso Elisabetta Faggin Nathalie Rosenblatt-Velin Maxime Pellegrin Silvia Galliazzo Luca Calanca Marcello Rattazzi Lucia Mazzolai |
| author_sort | Giacomo Buso |
| collection | DOAJ |
| description | In recent years, increasing attention has been paid to the role of neutrophils in cardiovascular (CV) disease (CVD) with evidence supporting their role in the initiation, progression, and rupture of atherosclerotic plaque. Although these cells have long been considered as terminally differentiated cells with a relatively limited spectrum of action, recent research has revealed intriguing novel cellular functions, including neutrophil extracellular trap (NET) generation and inflammasome activation, which have been linked to several human diseases, including CVD. While most research to date has focused on the role of neutrophils in coronary artery and cerebrovascular diseases, much less information is available on lower limb peripheral artery disease (PAD). PAD is a widespread condition associated with great morbidity and mortality, though physician and patient awareness of the disease remains low. To date, several studies have produced some evidence on the role of certain biomarkers of neutrophil activation in this clinical setting. However, the etiopathogenetic role of neutrophils, and in particular of some of the newly discovered mechanisms, has yet to be fully elucidated. In the future, complementary assessment of neutrophil activity should improve CV risk stratification and provide personalized treatments to patients with PAD. This review aims to summarize the basic principles and recent advances in the understanding of neutrophil biology, current knowledge about the role of neutrophils in atherosclerosis, as well as available evidence on their role of PAD. |
| first_indexed | 2024-03-09T12:24:25Z |
| format | Article |
| id | doaj.art-083232833f7044edbdece18190228103 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:24:25Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-083232833f7044edbdece181902281032023-11-30T22:36:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242116910.3390/ijms24021169The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future PerspectivesGiacomo Buso0Elisabetta Faggin1Nathalie Rosenblatt-Velin2Maxime Pellegrin3Silvia Galliazzo4Luca Calanca5Marcello Rattazzi6Lucia Mazzolai7Angiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Medicine—DIMED, University of Padua, 35128 Padua, ItalyAngiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandAngiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Internal Medicine Unit, Ospedale S. Valentino, 31044 Montebelluna, ItalyAngiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Medicine—DIMED, University of Padua, 35128 Padua, ItalyAngiology Division, Heart and Vessel Department, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandIn recent years, increasing attention has been paid to the role of neutrophils in cardiovascular (CV) disease (CVD) with evidence supporting their role in the initiation, progression, and rupture of atherosclerotic plaque. Although these cells have long been considered as terminally differentiated cells with a relatively limited spectrum of action, recent research has revealed intriguing novel cellular functions, including neutrophil extracellular trap (NET) generation and inflammasome activation, which have been linked to several human diseases, including CVD. While most research to date has focused on the role of neutrophils in coronary artery and cerebrovascular diseases, much less information is available on lower limb peripheral artery disease (PAD). PAD is a widespread condition associated with great morbidity and mortality, though physician and patient awareness of the disease remains low. To date, several studies have produced some evidence on the role of certain biomarkers of neutrophil activation in this clinical setting. However, the etiopathogenetic role of neutrophils, and in particular of some of the newly discovered mechanisms, has yet to be fully elucidated. In the future, complementary assessment of neutrophil activity should improve CV risk stratification and provide personalized treatments to patients with PAD. This review aims to summarize the basic principles and recent advances in the understanding of neutrophil biology, current knowledge about the role of neutrophils in atherosclerosis, as well as available evidence on their role of PAD.https://www.mdpi.com/1422-0067/24/2/1169peripheral artery diseaseatherosclerosisneutrophil activationneutrophil extracellular trapsinflammasome |
| spellingShingle | Giacomo Buso Elisabetta Faggin Nathalie Rosenblatt-Velin Maxime Pellegrin Silvia Galliazzo Luca Calanca Marcello Rattazzi Lucia Mazzolai The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives International Journal of Molecular Sciences peripheral artery disease atherosclerosis neutrophil activation neutrophil extracellular traps inflammasome |
| title | The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives |
| title_full | The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives |
| title_fullStr | The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives |
| title_full_unstemmed | The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives |
| title_short | The Role of Neutrophils in Lower Limb Peripheral Artery Disease: State of the Art and Future Perspectives |
| title_sort | role of neutrophils in lower limb peripheral artery disease state of the art and future perspectives |
| topic | peripheral artery disease atherosclerosis neutrophil activation neutrophil extracellular traps inflammasome |
| url | https://www.mdpi.com/1422-0067/24/2/1169 |
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