Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors
Background: Infants born with Very Low Birth Weight (< 1500 grams) and Extremely Low Birth Weight (< 1000 grams) are at a high risk of pre-discharge morbidities. Aim of our study was to know the incidence of colonization of the preterm neonates’ gastric aspirate and to co-relate it with the va...
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| Format: | Article |
| Language: | English |
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Gujarat Adani Institute of Medical Sciences
2023-04-01
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| Series: | GAIMS Journal of Medical Sciences |
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| Online Access: | https://gjms.gaims.ac.in/index.php/gjms/article/view/64/74 |
| _version_ | 1797812555882692608 |
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| author | Gopi Solanki Gargi Nayak Ekta Thacker Rekha Thaddanee Parth Sanandiya |
| author_facet | Gopi Solanki Gargi Nayak Ekta Thacker Rekha Thaddanee Parth Sanandiya |
| author_sort | Gopi Solanki |
| collection | DOAJ |
| description | Background: Infants born with Very Low Birth Weight (< 1500 grams) and Extremely Low Birth Weight (< 1000 grams) are at a high risk of pre-discharge morbidities. Aim of our study was to know the incidence of colonization of the preterm neonates’ gastric aspirate and to co-relate it with the various neonatal, maternal and environmental risk factors.
Material and Methods: This was a prospective, observational study in 100 neonates conducted over a period of two years at Pediatrics Department of a teaching hospital of Western Gujarat region. All pre-term newborns who did not have any clinical features for sepsis were included in the study.
Results: In our study, most common organisms isolated were enterococcus (41%) followed by bacteroids (26%) and staphylococcus (14%) in 24 hours & 72 hours of gastric aspirate sample. Lower gestation age and low birth weight were significantly associated with colonization of the preterm neonatal gut (p<0.05). The positive colonization was also significantly correlated to low APGAR score. Highest incidence of neonatal sepsis was seen with enterococci organism (14.6%), where six newborns with enterococci isolates in gastric aspirate had developed neonatal sepsis, followed by E. coli isolates (12.5%).
Conclusions: We found a high incidence of colonization of the preterm neonates’ gut, with enterococcus being the most common isolate. A significant association was observed between gut colonization and development of neonatal sepsis. Significant factors for development of gut colonization were: lower gestation age, multiple per-vaginal examinations and low birth weight of the newborns. |
| first_indexed | 2024-03-13T07:39:17Z |
| format | Article |
| id | doaj.art-0834f216af7749dc861004abaf59b5da |
| institution | Directory Open Access Journal |
| issn | 2583-1763 |
| language | English |
| last_indexed | 2024-03-13T07:39:17Z |
| publishDate | 2023-04-01 |
| publisher | Gujarat Adani Institute of Medical Sciences |
| record_format | Article |
| series | GAIMS Journal of Medical Sciences |
| spelling | doaj.art-0834f216af7749dc861004abaf59b5da2023-06-03T15:27:26ZengGujarat Adani Institute of Medical SciencesGAIMS Journal of Medical Sciences2583-17632023-04-013271010.5281/zenodo.7811864Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factorsGopi Solanki0Gargi Nayak1Ekta Thacker2Rekha Thaddanee3https://orcid.org/0000-0001-9503-6388Parth Sanandiya4Department of Paediatrics, GMERS Medical College and Hospital, Junagadh, GujaratDepartment of Paediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratDepartment of Paediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratDepartment of Paediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratDepartment of Paediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Kachchh, GujaratBackground: Infants born with Very Low Birth Weight (< 1500 grams) and Extremely Low Birth Weight (< 1000 grams) are at a high risk of pre-discharge morbidities. Aim of our study was to know the incidence of colonization of the preterm neonates’ gastric aspirate and to co-relate it with the various neonatal, maternal and environmental risk factors. Material and Methods: This was a prospective, observational study in 100 neonates conducted over a period of two years at Pediatrics Department of a teaching hospital of Western Gujarat region. All pre-term newborns who did not have any clinical features for sepsis were included in the study. Results: In our study, most common organisms isolated were enterococcus (41%) followed by bacteroids (26%) and staphylococcus (14%) in 24 hours & 72 hours of gastric aspirate sample. Lower gestation age and low birth weight were significantly associated with colonization of the preterm neonatal gut (p<0.05). The positive colonization was also significantly correlated to low APGAR score. Highest incidence of neonatal sepsis was seen with enterococci organism (14.6%), where six newborns with enterococci isolates in gastric aspirate had developed neonatal sepsis, followed by E. coli isolates (12.5%). Conclusions: We found a high incidence of colonization of the preterm neonates’ gut, with enterococcus being the most common isolate. A significant association was observed between gut colonization and development of neonatal sepsis. Significant factors for development of gut colonization were: lower gestation age, multiple per-vaginal examinations and low birth weight of the newborns.https://gjms.gaims.ac.in/index.php/gjms/article/view/64/74enterococcusintestinal bacterianeonatesneonatal sepsisgastric aspirate |
| spellingShingle | Gopi Solanki Gargi Nayak Ekta Thacker Rekha Thaddanee Parth Sanandiya Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors GAIMS Journal of Medical Sciences enterococcus intestinal bacteria neonates neonatal sepsis gastric aspirate |
| title | Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors |
| title_full | Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors |
| title_fullStr | Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors |
| title_full_unstemmed | Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors |
| title_short | Incidence of colonization of preterm neonates’ gastric aspirate and its correlation with neonatal, maternal and environmental risk factors |
| title_sort | incidence of colonization of preterm neonates gastric aspirate and its correlation with neonatal maternal and environmental risk factors |
| topic | enterococcus intestinal bacteria neonates neonatal sepsis gastric aspirate |
| url | https://gjms.gaims.ac.in/index.php/gjms/article/view/64/74 |
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