Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety
Chronic sleep restriction, or inadequate sleep, is associated with increased risk of cardiometabolic disease. Laboratory studies demonstrate that sleep restriction causes impaired whole-body insulin sensitivity and glucose disposal. Evidence suggests that inadequate sleep also impairs adipose tissue...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520322914 |
| _version_ | 1818661906907398144 |
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| author | Kelly M. Ness Stephen M. Strayer Nicole G. Nahmod Margeaux M. Schade Anne-Marie Chang Gregory C. Shearer Orfeu M. Buxton |
| author_facet | Kelly M. Ness Stephen M. Strayer Nicole G. Nahmod Margeaux M. Schade Anne-Marie Chang Gregory C. Shearer Orfeu M. Buxton |
| author_sort | Kelly M. Ness |
| collection | DOAJ |
| description | Chronic sleep restriction, or inadequate sleep, is associated with increased risk of cardiometabolic disease. Laboratory studies demonstrate that sleep restriction causes impaired whole-body insulin sensitivity and glucose disposal. Evidence suggests that inadequate sleep also impairs adipose tissue insulin sensitivity and the NEFA rebound during intravenous glucose tolerance tests, yet no studies have examined the effects of sleep restriction on high-fat meal lipemia. We assessed the effect of 5 h time in bed (TIB) per night for four consecutive nights on postprandial lipemia following a standardized high-fat dinner (HFD). Furthermore, we assessed whether one night of recovery sleep (10 h TIB) was sufficient to restore postprandial metabolism to baseline. We found that postprandial triglyceride (TG) area under the curve was suppressed by sleep restriction (P = 0.01), but returned to baseline values following one night of recovery. Sleep restriction decreased NEFAs throughout the HFD (P = 0.02) and NEFAs remained suppressed in the recovery condition (P = 0.04). Sleep restriction also decreased participant-reported fullness or satiety (P = 0.03), and decreased postprandial interleukin-6 (P < 0.01). Our findings indicate that four nights of 5 h TIB per night impair postprandial lipemia and that one night of recovery sleep may be adequate for recovery of TG metabolism, but not for markers of adipocyte function. |
| first_indexed | 2024-12-17T04:52:30Z |
| format | Article |
| id | doaj.art-0838256674a84c35a014e47b093ea6a1 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T04:52:30Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-0838256674a84c35a014e47b093ea6a12022-12-21T22:02:51ZengElsevierJournal of Lipid Research0022-22752019-11-01601119351945Four nights of sleep restriction suppress the postprandial lipemic response and decrease satietyKelly M. Ness0Stephen M. Strayer1Nicole G. Nahmod2Margeaux M. Schade3Anne-Marie Chang4Gregory C. Shearer5Orfeu M. Buxton6Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802; Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802; Nutritional Sciences, Pennsylvania State University, University Park, PA 16802Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802; Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802; Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802; College of Nursing, Pennsylvania State University, University Park, PA 16802Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802; Nutritional Sciences, Pennsylvania State University, University Park, PA 16802To whom correspondence should be addressed.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802; Departments of Biobehavioral Health Pennsylvania State University, University Park, PA 16802; Division of Sleep Medicine, Harvard Medical School, Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, and Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 20115; To whom correspondence should be addressed.Chronic sleep restriction, or inadequate sleep, is associated with increased risk of cardiometabolic disease. Laboratory studies demonstrate that sleep restriction causes impaired whole-body insulin sensitivity and glucose disposal. Evidence suggests that inadequate sleep also impairs adipose tissue insulin sensitivity and the NEFA rebound during intravenous glucose tolerance tests, yet no studies have examined the effects of sleep restriction on high-fat meal lipemia. We assessed the effect of 5 h time in bed (TIB) per night for four consecutive nights on postprandial lipemia following a standardized high-fat dinner (HFD). Furthermore, we assessed whether one night of recovery sleep (10 h TIB) was sufficient to restore postprandial metabolism to baseline. We found that postprandial triglyceride (TG) area under the curve was suppressed by sleep restriction (P = 0.01), but returned to baseline values following one night of recovery. Sleep restriction decreased NEFAs throughout the HFD (P = 0.02) and NEFAs remained suppressed in the recovery condition (P = 0.04). Sleep restriction also decreased participant-reported fullness or satiety (P = 0.03), and decreased postprandial interleukin-6 (P < 0.01). Our findings indicate that four nights of 5 h TIB per night impair postprandial lipemia and that one night of recovery sleep may be adequate for recovery of TG metabolism, but not for markers of adipocyte function.http://www.sciencedirect.com/science/article/pii/S0022227520322914triglyceridesnutritionlipolysis and fatty acid metabolismdiet and dietary lipidsfatty acidinsulin resistance |
| spellingShingle | Kelly M. Ness Stephen M. Strayer Nicole G. Nahmod Margeaux M. Schade Anne-Marie Chang Gregory C. Shearer Orfeu M. Buxton Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety Journal of Lipid Research triglycerides nutrition lipolysis and fatty acid metabolism diet and dietary lipids fatty acid insulin resistance |
| title | Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| title_full | Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| title_fullStr | Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| title_full_unstemmed | Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| title_short | Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| title_sort | four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety |
| topic | triglycerides nutrition lipolysis and fatty acid metabolism diet and dietary lipids fatty acid insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520322914 |
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