Cognitive control network connectivity in adolescent women with and without a parental history of depression
Background: Adolescent women with a parental history of depression are at high risk for the onset of major depressive disorder (MDD). Cognitive theories suggest this vulnerability involves deficits in cognitive control over emotional information. Among adolescent women with and without a parental hi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929313000674 |
| _version_ | 1811211523026059264 |
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| author | Peter C. Clasen Christopher G. Beevers Jeanette A. Mumford David M. Schnyer |
| author_facet | Peter C. Clasen Christopher G. Beevers Jeanette A. Mumford David M. Schnyer |
| author_sort | Peter C. Clasen |
| collection | DOAJ |
| description | Background: Adolescent women with a parental history of depression are at high risk for the onset of major depressive disorder (MDD). Cognitive theories suggest this vulnerability involves deficits in cognitive control over emotional information. Among adolescent women with and without a parental history of depression, we examined differences in connectivity using resting state functional connectivity analysis within a network associated with cognitive control over emotional information.
Methods: Twenty-four depression-naïve adolescent women underwent resting state functional magnetic resonance imaging (fMRI). They were assigned to high-risk (n = 11) and low-risk (n = 13) groups based their parents’ depression history. Seed based functional connectivity analysis was used to examine group differences in connectivity within a network associated with cognitive control.
Results: High-risk adolescents had lower levels of connectivity between a right inferior prefrontal region and other critical nodes of the attention control network, including right middle frontal gyrus and right supramarginal gyrus. Further, greater severity of the parents’ worst episode of depression was associated with altered cognitive control network connectivity in their adolescent daughters.
Conclusions: Depressed parents may transmit depression vulnerability to their adolescent daughters via alterations in functional connectivity within neural circuits that underlie cognitive control of emotional information. |
| first_indexed | 2024-04-12T05:15:31Z |
| format | Article |
| id | doaj.art-08394ce61f8249ab904830764ed4b04c |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-04-12T05:15:31Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-08394ce61f8249ab904830764ed4b04c2022-12-22T03:46:38ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072014-01-017C132210.1016/j.dcn.2013.10.008Cognitive control network connectivity in adolescent women with and without a parental history of depressionPeter C. Clasen0Christopher G. Beevers1Jeanette A. Mumford2David M. Schnyer3Department of Psychology, The University of Texas at Austin, United StatesDepartment of Psychology, The University of Texas at Austin, United StatesDepartment of Psychology, The University of Texas at Austin, United StatesDepartment of Psychology, The University of Texas at Austin, United StatesBackground: Adolescent women with a parental history of depression are at high risk for the onset of major depressive disorder (MDD). Cognitive theories suggest this vulnerability involves deficits in cognitive control over emotional information. Among adolescent women with and without a parental history of depression, we examined differences in connectivity using resting state functional connectivity analysis within a network associated with cognitive control over emotional information. Methods: Twenty-four depression-naïve adolescent women underwent resting state functional magnetic resonance imaging (fMRI). They were assigned to high-risk (n = 11) and low-risk (n = 13) groups based their parents’ depression history. Seed based functional connectivity analysis was used to examine group differences in connectivity within a network associated with cognitive control. Results: High-risk adolescents had lower levels of connectivity between a right inferior prefrontal region and other critical nodes of the attention control network, including right middle frontal gyrus and right supramarginal gyrus. Further, greater severity of the parents’ worst episode of depression was associated with altered cognitive control network connectivity in their adolescent daughters. Conclusions: Depressed parents may transmit depression vulnerability to their adolescent daughters via alterations in functional connectivity within neural circuits that underlie cognitive control of emotional information.http://www.sciencedirect.com/science/article/pii/S1878929313000674Depression vulnerabilityAdolescenceParental history of depressionCognitive control networkResting-state fMRIFunctional connectivity |
| spellingShingle | Peter C. Clasen Christopher G. Beevers Jeanette A. Mumford David M. Schnyer Cognitive control network connectivity in adolescent women with and without a parental history of depression Developmental Cognitive Neuroscience Depression vulnerability Adolescence Parental history of depression Cognitive control network Resting-state fMRI Functional connectivity |
| title | Cognitive control network connectivity in adolescent women with and without a parental history of depression |
| title_full | Cognitive control network connectivity in adolescent women with and without a parental history of depression |
| title_fullStr | Cognitive control network connectivity in adolescent women with and without a parental history of depression |
| title_full_unstemmed | Cognitive control network connectivity in adolescent women with and without a parental history of depression |
| title_short | Cognitive control network connectivity in adolescent women with and without a parental history of depression |
| title_sort | cognitive control network connectivity in adolescent women with and without a parental history of depression |
| topic | Depression vulnerability Adolescence Parental history of depression Cognitive control network Resting-state fMRI Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1878929313000674 |
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