Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany
ObjectiveStudies have shown an increased incidence of pediatric type 1 diabetes during the COVID-19 pandemic, but the detailed role of SARS-CoV-2 infection in the incidence increase in type 1 diabetes remains unclear. We investigated the spatiotemporal association of pediatric type 1 diabetes and CO...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287354/full |
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| author | Joachim Rosenbauer Joachim Rosenbauer Anna Stahl-Pehe Anna Stahl-Pehe Christina Baechle Christina Baechle Stefanie Lanzinger Stefanie Lanzinger Clemens Kamrath Oliver Kuß Oliver Kuß Oliver Kuß Reinhard W. Holl Reinhard W. Holl |
| author_facet | Joachim Rosenbauer Joachim Rosenbauer Anna Stahl-Pehe Anna Stahl-Pehe Christina Baechle Christina Baechle Stefanie Lanzinger Stefanie Lanzinger Clemens Kamrath Oliver Kuß Oliver Kuß Oliver Kuß Reinhard W. Holl Reinhard W. Holl |
| author_sort | Joachim Rosenbauer |
| collection | DOAJ |
| description | ObjectiveStudies have shown an increased incidence of pediatric type 1 diabetes during the COVID-19 pandemic, but the detailed role of SARS-CoV-2 infection in the incidence increase in type 1 diabetes remains unclear. We investigated the spatiotemporal association of pediatric type 1 diabetes and COVID-19 incidence at the district level in Germany.MethodsFor the period from March 2020 to June 2022, nationwide data on incident type 1 diabetes among children and adolescents aged <20 years and daily documented COVID-19 infections in the total population were obtained from the German Diabetes Prospective Follow-up Registry and the Robert Koch Institute, respectively. Data were aggregated at district level and seven time periods related to COVID-19 pandemic waves. Spatiotemporal associations between indirectly standardized incidence rates of type 1 diabetes and COVID-19 were analyzed by Spearman correlation and Bayesian spatiotemporal conditional autoregressive Poisson models.ResultsStandardized incidence ratios of type 1 diabetes and COVID-19 in the pandemic period were not significantly correlated across districts and time periods. A doubling of the COVID-19 incidence rate was not associated with a significant increase in the incidence rate of type 1 diabetes (relative risk 1.006, 95% CI 0.987; 1.019).ConclusionOur findings based on data from the pandemic period indirectly indicate that a causal relationship between SARS-COV-2 infection and type 1 diabetes among children and adolescents is unlikely. |
| first_indexed | 2024-03-08T17:21:24Z |
| format | Article |
| id | doaj.art-083b28fb323e4adbab178db06b36dfb6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T17:21:24Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-083b28fb323e4adbab178db06b36dfb62024-01-03T04:38:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12873541287354Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in GermanyJoachim Rosenbauer0Joachim Rosenbauer1Anna Stahl-Pehe2Anna Stahl-Pehe3Christina Baechle4Christina Baechle5Stefanie Lanzinger6Stefanie Lanzinger7Clemens Kamrath8Oliver Kuß9Oliver Kuß10Oliver Kuß11Reinhard W. Holl12Reinhard W. Holl13Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyInstitute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology (ZIBMT), Ulm University, Ulm, GermanyCenter of Child and Adolescent Medicine, Justus Liebig University Giessen, Giessen, GermanyInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyCentre for Health and Society, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyGerman Center for Diabetes Research (DZD), Munich, GermanyInstitute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology (ZIBMT), Ulm University, Ulm, GermanyObjectiveStudies have shown an increased incidence of pediatric type 1 diabetes during the COVID-19 pandemic, but the detailed role of SARS-CoV-2 infection in the incidence increase in type 1 diabetes remains unclear. We investigated the spatiotemporal association of pediatric type 1 diabetes and COVID-19 incidence at the district level in Germany.MethodsFor the period from March 2020 to June 2022, nationwide data on incident type 1 diabetes among children and adolescents aged <20 years and daily documented COVID-19 infections in the total population were obtained from the German Diabetes Prospective Follow-up Registry and the Robert Koch Institute, respectively. Data were aggregated at district level and seven time periods related to COVID-19 pandemic waves. Spatiotemporal associations between indirectly standardized incidence rates of type 1 diabetes and COVID-19 were analyzed by Spearman correlation and Bayesian spatiotemporal conditional autoregressive Poisson models.ResultsStandardized incidence ratios of type 1 diabetes and COVID-19 in the pandemic period were not significantly correlated across districts and time periods. A doubling of the COVID-19 incidence rate was not associated with a significant increase in the incidence rate of type 1 diabetes (relative risk 1.006, 95% CI 0.987; 1.019).ConclusionOur findings based on data from the pandemic period indirectly indicate that a causal relationship between SARS-COV-2 infection and type 1 diabetes among children and adolescents is unlikely.https://www.frontiersin.org/articles/10.3389/fendo.2023.1287354/fullcoronavirus disease 2019 (COVID-19)type 1 diabetesincidence ratechildren and adolescentsepidemiologyregistry |
| spellingShingle | Joachim Rosenbauer Joachim Rosenbauer Anna Stahl-Pehe Anna Stahl-Pehe Christina Baechle Christina Baechle Stefanie Lanzinger Stefanie Lanzinger Clemens Kamrath Oliver Kuß Oliver Kuß Oliver Kuß Reinhard W. Holl Reinhard W. Holl Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany Frontiers in Endocrinology coronavirus disease 2019 (COVID-19) type 1 diabetes incidence rate children and adolescents epidemiology registry |
| title | Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany |
| title_full | Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany |
| title_fullStr | Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany |
| title_full_unstemmed | Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany |
| title_short | Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany |
| title_sort | spatiotemporal association between covid 19 incidence and type 1 diabetes incidence among children and adolescents a register based ecological study in germany |
| topic | coronavirus disease 2019 (COVID-19) type 1 diabetes incidence rate children and adolescents epidemiology registry |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287354/full |
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