Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats
Currently, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and more functional foods are needed for NAFLD prevention and treatment. Kaempferol can be obtained from tea, broccoli, propolis, grapefruit and other green plants. However, relatively systematic studies...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621003042 |
| _version_ | 1819137748973387776 |
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| author | Panpan Liu Peixuan Wu Bendong Yang Tianqi Wang Jingda Li Xinhua Song Wenlong Sun |
| author_facet | Panpan Liu Peixuan Wu Bendong Yang Tianqi Wang Jingda Li Xinhua Song Wenlong Sun |
| author_sort | Panpan Liu |
| collection | DOAJ |
| description | Currently, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and more functional foods are needed for NAFLD prevention and treatment. Kaempferol can be obtained from tea, broccoli, propolis, grapefruit and other green plants. However, relatively systematic studies concerning the preventative effects of kaempferol against NAFLD are lacking. In this study, using network pharmacological methods, we found that kaempferol could prevent the development of NAFLD by targeting multiple targets; for instance, kaempferol suppressed inflammation, improved insulin resistance and reduced oxidative stress. Furthermore, we confirmed that kaempferol could suppress inflammatory responses and prevent the development of NAFLD in vitro and in vivo by inhibiting the nuclear transcriptional activity of NF-κB. Our study supports the use of kaempferol as a functional food or dietary supplement for NAFLD prevention and treatment. In addition, this study could be beneficial for understanding the anti-NAFLD mechanism of many other flavonoids. |
| first_indexed | 2024-12-22T10:55:49Z |
| format | Article |
| id | doaj.art-083b809a500946d189cd04c5c4cb1f0c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-22T10:55:49Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-083b809a500946d189cd04c5c4cb1f0c2022-12-21T18:28:37ZengElsevierJournal of Functional Foods1756-46462021-10-0185104655Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced ratsPanpan Liu0Peixuan Wu1Bendong Yang2Tianqi Wang3Jingda Li4Xinhua Song5Wenlong Sun6Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of ChinaInstitute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of ChinaInstitute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of ChinaCollege of Agriculture, Yangtze University, Jingzhou, Hubei 434000, People’s Republic of ChinaCollege of Life Science, Yangtze University, Jingzhou, Hubei 434000, People’s Republic of ChinaInstitute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of China; Shandong Qingyujiangxing Biotechnology Co, Ltd, Zibo, Shandong 255000, People’s Republic of China; Corresponding authors at: Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of China.Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of China; Shandong Qingyujiangxing Biotechnology Co, Ltd, Zibo, Shandong 255000, People’s Republic of China; Corresponding authors at: Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong 255000, People’s Republic of China.Currently, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and more functional foods are needed for NAFLD prevention and treatment. Kaempferol can be obtained from tea, broccoli, propolis, grapefruit and other green plants. However, relatively systematic studies concerning the preventative effects of kaempferol against NAFLD are lacking. In this study, using network pharmacological methods, we found that kaempferol could prevent the development of NAFLD by targeting multiple targets; for instance, kaempferol suppressed inflammation, improved insulin resistance and reduced oxidative stress. Furthermore, we confirmed that kaempferol could suppress inflammatory responses and prevent the development of NAFLD in vitro and in vivo by inhibiting the nuclear transcriptional activity of NF-κB. Our study supports the use of kaempferol as a functional food or dietary supplement for NAFLD prevention and treatment. In addition, this study could be beneficial for understanding the anti-NAFLD mechanism of many other flavonoids.http://www.sciencedirect.com/science/article/pii/S1756464621003042NAFLDSSNASHNF-κBKaempferol |
| spellingShingle | Panpan Liu Peixuan Wu Bendong Yang Tianqi Wang Jingda Li Xinhua Song Wenlong Sun Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats Journal of Functional Foods NAFLD SS NASH NF-κB Kaempferol |
| title | Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats |
| title_full | Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats |
| title_fullStr | Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats |
| title_full_unstemmed | Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats |
| title_short | Kaempferol prevents the progression from simple steatosis to non-alcoholic steatohepatitis by inhibiting the NF-κB pathway in oleic acid-induced HepG2 cells and high-fat diet-induced rats |
| title_sort | kaempferol prevents the progression from simple steatosis to non alcoholic steatohepatitis by inhibiting the nf κb pathway in oleic acid induced hepg2 cells and high fat diet induced rats |
| topic | NAFLD SS NASH NF-κB Kaempferol |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621003042 |
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