Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension
The pathological mechanisms underlying pulmonary hypertension (PH), as well as its treatment strategy, are crucial issues in this field. This review aimed to summarize the pathological mechanisms by which the hydrogen sulfide (H<sub>2</sub>S) pathway contributes to PH development and its...
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MDPI AG
2022-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/6/772 |
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| author | Yan Sun Chaoshu Tang Hongfang Jin Junbao Du |
| author_facet | Yan Sun Chaoshu Tang Hongfang Jin Junbao Du |
| author_sort | Yan Sun |
| collection | DOAJ |
| description | The pathological mechanisms underlying pulmonary hypertension (PH), as well as its treatment strategy, are crucial issues in this field. This review aimed to summarize the pathological mechanisms by which the hydrogen sulfide (H<sub>2</sub>S) pathway contributes to PH development and its future implications. The data in this review were obtained from Medline and PubMed sources up to 2022 using the search terms "hydrogen sulfide" and "pulmonary hypertension". In the review, we discussed the significance of endogenous H<sub>2</sub>S pathway alteration in PH development and showed the advance of the role of H<sub>2</sub>S as the third gasotransmitter in the mechanisms for hypoxic PH, monocrotaline-induced PH, high blood flow-induced PH, and congenital heart disease-associated PH. Notably, H<sub>2</sub>S plays a crucial role in the development of PH via certain mechanisms, such as inhibiting the proliferation of pulmonary artery smooth muscle cells, suppressing the inflammation and oxidative stress of pulmonary artery endothelial cells, inducing pulmonary artery smooth muscle cell apoptosis, and interacting with other gaseous signaling pathways. Recently, a variety of H<sub>2</sub>S donors were developed, including naturally occurring donors and synthetic H<sub>2</sub>S donors. Therefore, understanding the role of H<sub>2</sub>S in PH development may help in further exploring novel potential therapeutic targets of PH. |
| first_indexed | 2024-03-10T00:18:33Z |
| format | Article |
| id | doaj.art-083bacbef92f4651a2f616583a7996bd |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T00:18:33Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-083bacbef92f4651a2f616583a7996bd2023-11-23T15:46:39ZengMDPI AGBiomolecules2218-273X2022-06-0112677210.3390/biom12060772Implications of Hydrogen Sulfide in Development of Pulmonary HypertensionYan Sun0Chaoshu Tang1Hongfang Jin2Junbao Du3Department of Pediatrics, Peking University First Hospital, Beijing 100034, ChinaKey Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, ChinaThe pathological mechanisms underlying pulmonary hypertension (PH), as well as its treatment strategy, are crucial issues in this field. This review aimed to summarize the pathological mechanisms by which the hydrogen sulfide (H<sub>2</sub>S) pathway contributes to PH development and its future implications. The data in this review were obtained from Medline and PubMed sources up to 2022 using the search terms "hydrogen sulfide" and "pulmonary hypertension". In the review, we discussed the significance of endogenous H<sub>2</sub>S pathway alteration in PH development and showed the advance of the role of H<sub>2</sub>S as the third gasotransmitter in the mechanisms for hypoxic PH, monocrotaline-induced PH, high blood flow-induced PH, and congenital heart disease-associated PH. Notably, H<sub>2</sub>S plays a crucial role in the development of PH via certain mechanisms, such as inhibiting the proliferation of pulmonary artery smooth muscle cells, suppressing the inflammation and oxidative stress of pulmonary artery endothelial cells, inducing pulmonary artery smooth muscle cell apoptosis, and interacting with other gaseous signaling pathways. Recently, a variety of H<sub>2</sub>S donors were developed, including naturally occurring donors and synthetic H<sub>2</sub>S donors. Therefore, understanding the role of H<sub>2</sub>S in PH development may help in further exploring novel potential therapeutic targets of PH.https://www.mdpi.com/2218-273X/12/6/772hydrogen sulfidepulmonary hypertensionremodelingpulmonary artery |
| spellingShingle | Yan Sun Chaoshu Tang Hongfang Jin Junbao Du Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension Biomolecules hydrogen sulfide pulmonary hypertension remodeling pulmonary artery |
| title | Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension |
| title_full | Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension |
| title_fullStr | Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension |
| title_full_unstemmed | Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension |
| title_short | Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension |
| title_sort | implications of hydrogen sulfide in development of pulmonary hypertension |
| topic | hydrogen sulfide pulmonary hypertension remodeling pulmonary artery |
| url | https://www.mdpi.com/2218-273X/12/6/772 |
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