CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE
The study of disorders of systemic immunity and immune regulation in idiopathic transient synovitis of the hip joint (ITSHJ) and disease Legg-Calve-Perthes (DP) in children of early and school age. Studied 37 children with ITSHJ and 11 children with DP in the age interval of 3-12 years. The control...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2017-08-01
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| Series: | Мать и дитя в Кузбассе |
| Subjects: | |
| Online Access: | http://mednauki.ru/index.php/MD/article/view/115 |
| _version_ | 1818513330929664000 |
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| author | Никита Андреевич Шабалдин Сергей Иванович Головкин Андрей Владимирович Шабалдин |
| author_facet | Никита Андреевич Шабалдин Сергей Иванович Головкин Андрей Владимирович Шабалдин |
| author_sort | Никита Андреевич Шабалдин |
| collection | DOAJ |
| description | The study of disorders of systemic immunity and immune regulation in idiopathic transient synovitis of the hip joint (ITSHJ) and disease Legg-Calve-Perthes (DP) in children of early and school age. Studied 37 children with ITSHJ and 11 children with DP in the age interval of 3-12 years. The control group consisted of 29 healthy children. Investigated cytokine levels in the peripheral blood and the level of antibodies to conditionally pathogenic microflora. It is shown that ITSHJ and DP different in the immunopathogenesis of the disease. ITSHJ associated with allergic (atopic and immune) immune response to the antigens of pathogenic microorganisms and the herpes viruses and the development of infectious and allergic inflammation. DP associated with aseptic inflammation, developing on the background of high activity of IL-1Ra, TNF-a and induction of the rheumatoid factor. Pathogenetically justified in this pathology will be the appointment of drugs blocks the activity of TNF-a. |
| first_indexed | 2024-12-10T23:59:50Z |
| format | Article |
| id | doaj.art-083c3f78d0fa4245979488e348715ce9 |
| institution | Directory Open Access Journal |
| issn | 2542-0968 2542-0968 |
| language | Russian |
| last_indexed | 2024-12-10T23:59:50Z |
| publishDate | 2017-08-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj.art-083c3f78d0fa4245979488e348715ce92022-12-22T01:28:30ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе2542-09682542-09682017-08-011712126103CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGEНикита Андреевич Шабалдин0Сергей Иванович Головкин1Андрей Владимирович Шабалдин2ГБОУ ВПО КемГМА Минздрава России, г. КемеровоГБОУ ВПО КемГМА Минздрава России, г. КемеровоФГБНУ «НИИ Комплексных проблем сердечно-сосудистых заболеваний» СО РАМН, г. КемеровоThe study of disorders of systemic immunity and immune regulation in idiopathic transient synovitis of the hip joint (ITSHJ) and disease Legg-Calve-Perthes (DP) in children of early and school age. Studied 37 children with ITSHJ and 11 children with DP in the age interval of 3-12 years. The control group consisted of 29 healthy children. Investigated cytokine levels in the peripheral blood and the level of antibodies to conditionally pathogenic microflora. It is shown that ITSHJ and DP different in the immunopathogenesis of the disease. ITSHJ associated with allergic (atopic and immune) immune response to the antigens of pathogenic microorganisms and the herpes viruses and the development of infectious and allergic inflammation. DP associated with aseptic inflammation, developing on the background of high activity of IL-1Ra, TNF-a and induction of the rheumatoid factor. Pathogenetically justified in this pathology will be the appointment of drugs blocks the activity of TNF-a.http://mednauki.ru/index.php/MD/article/view/115иммунный статустранзиторный синовит тазобедреного суставаболезнь легга-кальве-пертесадети |
| spellingShingle | Никита Андреевич Шабалдин Сергей Иванович Головкин Андрей Владимирович Шабалдин CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE Мать и дитя в Кузбассе иммунный статус транзиторный синовит тазобедреного сустава болезнь легга-кальве-пертеса дети |
| title | CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE |
| title_full | CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE |
| title_fullStr | CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE |
| title_full_unstemmed | CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE |
| title_short | CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE |
| title_sort | clinical and immunological features of transient synovitis of the hip joint and disease legg calve perthes in children of early and school age |
| topic | иммунный статус транзиторный синовит тазобедреного сустава болезнь легга-кальве-пертеса дети |
| url | http://mednauki.ru/index.php/MD/article/view/115 |
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