Protective effect of silymarin against chemical-induced cardiotoxicity
Cardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-09-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_7590_84dc813159e5eff60d9cd251d6fe7982.pdf |
| _version_ | 1818359597258244096 |
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| author | Bibi Marjan Razavi Gholamreza Karimi |
| author_facet | Bibi Marjan Razavi Gholamreza Karimi |
| author_sort | Bibi Marjan Razavi |
| collection | DOAJ |
| description | Cardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. There is a large body of evidence that administration of antioxidants may be useful in ameliorating cardiac toxicity. Silymarin, a polyphenolic flavonoid has been shown to have utility in several cardiovascular disorders. In this review, various studies in scientific databases regarding the preventive effects of silymarin against cardiotoxicity induced by chemicals were introduced. Although there are many studies representing the valuable effects of silymarin in different diseases, the number of researches relating to the possible cardiac protective effects of silymarin against drugs induced toxicity is rather limited. Results of these studies show that silymarin has a broad spectrum of cardiac protective activity against toxicity induced by some chemicals including metals, environmental pollutants, oxidative agents and anticancer drugs. Further studies are needed to establish the utility of silymarin in protection against cardiac toxicity. |
| first_indexed | 2024-12-13T20:47:25Z |
| format | Article |
| id | doaj.art-083eb19dc53446d3be35b06abc9bfe8f |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-13T20:47:25Z |
| publishDate | 2016-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-083eb19dc53446d3be35b06abc9bfe8f2022-12-21T23:31:58ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-09-0119991692310.22038/ijbms.2016.75907590Protective effect of silymarin against chemical-induced cardiotoxicityBibi Marjan Razavi0Gholamreza Karimi1Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmacy School, Mashhad University of Medical Sciences, Mashhad, IranCardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. There is a large body of evidence that administration of antioxidants may be useful in ameliorating cardiac toxicity. Silymarin, a polyphenolic flavonoid has been shown to have utility in several cardiovascular disorders. In this review, various studies in scientific databases regarding the preventive effects of silymarin against cardiotoxicity induced by chemicals were introduced. Although there are many studies representing the valuable effects of silymarin in different diseases, the number of researches relating to the possible cardiac protective effects of silymarin against drugs induced toxicity is rather limited. Results of these studies show that silymarin has a broad spectrum of cardiac protective activity against toxicity induced by some chemicals including metals, environmental pollutants, oxidative agents and anticancer drugs. Further studies are needed to establish the utility of silymarin in protection against cardiac toxicity.http://ijbms.mums.ac.ir/article_7590_84dc813159e5eff60d9cd251d6fe7982.pdfCardiotoxicityMetalsOxidative stressSilybum marianumSilymarin |
| spellingShingle | Bibi Marjan Razavi Gholamreza Karimi Protective effect of silymarin against chemical-induced cardiotoxicity Iranian Journal of Basic Medical Sciences Cardiotoxicity Metals Oxidative stress Silybum marianum Silymarin |
| title | Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_full | Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_fullStr | Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_full_unstemmed | Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_short | Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_sort | protective effect of silymarin against chemical induced cardiotoxicity |
| topic | Cardiotoxicity Metals Oxidative stress Silybum marianum Silymarin |
| url | http://ijbms.mums.ac.ir/article_7590_84dc813159e5eff60d9cd251d6fe7982.pdf |
| work_keys_str_mv | AT bibimarjanrazavi protectiveeffectofsilymarinagainstchemicalinducedcardiotoxicity AT gholamrezakarimi protectiveeffectofsilymarinagainstchemicalinducedcardiotoxicity |