Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study
Introduction: The Assessment of Spondylo Arthritis International Society (ASAS) classification criteria for Axial Spondyloarthropathy (axSpA) published in 2009 aimed to achieve a greater sensitivity in diagnosing patients of axial spondyloarthritis. Whether the radiographic form Ankylosing Spondylit...
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JCDR Research and Publications Private Limited
2018-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11493/35982_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PFA(AJ_SL)_PB(AJ_SL)_PN(SL).pdf |
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| author | Uday Prabhakar Anup Singh |
| author_facet | Uday Prabhakar Anup Singh |
| author_sort | Uday Prabhakar |
| collection | DOAJ |
| description | Introduction: The Assessment of Spondylo Arthritis International Society (ASAS) classification criteria for Axial Spondyloarthropathy (axSpA) published in 2009 aimed to achieve a greater sensitivity in diagnosing patients of axial spondyloarthritis. Whether the radiographic form Ankylosing Spondylitis (AS) and the Non Radiographic Axial Spondyloarthritis (nr-axSpA) form, are subgroups or different phases of the same disease is a pertinent question because this could have affected the pharmacological management of the two subgroup. Whether a distinction between AS and nr-axSpA in clinical practice is useful, remains unknown. Therefore, the present study was undertaken with the following aim. Aim: To investigate the differences in clinical presentation and disease activity between nr-axSpA and AS. Materials and Methods: A cross sectional study was conducted in Division of Rheumatology, Banaras Hindu University, Varanasi, India from January 2016 to June 2017. All the patients presenting with history of chronic back pain for ≥3 months and age at onset ≤45 years after taking written informed consent were included in the study. Using the ASAS criteria, patients were then classified into two groups of 50 patients each, patients having AS (if there was sacroilitis on radiographs as defined in modified New York criteria) and nr-axSpA diagnosed using ASAS criteria. The various SpA related variables were then compared including gender, age, duration of illness, enthesitis, dactylitis, uveitis, peripheral arthritis, psoriasis, family history, Human Leucocyte Antigen (HLA) B27 positivity, baseline C-Reactive Protein (CRP), baseline Erythrocyte Sedimentation Rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Results: Patients with AS, as compared with nr-axSpA had a longer disease duration {4.5(1.875-8.250) vs. 2.0(1.000- 4.000); p-value 0.023} and had a significantly higher levels of objective markers of inflammation i.e., CRP {4.7(2.325-6.525) vs. 2.20(0.588-4.125); p-value<0.001)} and ESR {(41.98±16.936 vs. 34.20±14.552; p-value 0.015)}. No statistically significant difference was found in age of onset, male: female ratio, enthesitis, dactylitis, uveitis, peripheral arthritis, psoriasis, family history and HLAB27 positivity. Neither any statistically significant difference was noted between the mean BASDAI and BASFI in the two groups. Conclusion: Other than elevated levels of markers of inflammation (CRP/ESR) and a longer disease duration in AS, most other features do not vary significantly between the two groups. Thus, the two groups might represent same disease in different phases. |
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| spelling | doaj.art-08439dd0852446b99db32043015416c72022-12-21T23:32:43ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-05-01125OC15OC1810.7860/JCDR/2018/35982.11493Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional StudyUday Prabhakar0Anup Singh1Junior Resident, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Associate Professor, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Introduction: The Assessment of Spondylo Arthritis International Society (ASAS) classification criteria for Axial Spondyloarthropathy (axSpA) published in 2009 aimed to achieve a greater sensitivity in diagnosing patients of axial spondyloarthritis. Whether the radiographic form Ankylosing Spondylitis (AS) and the Non Radiographic Axial Spondyloarthritis (nr-axSpA) form, are subgroups or different phases of the same disease is a pertinent question because this could have affected the pharmacological management of the two subgroup. Whether a distinction between AS and nr-axSpA in clinical practice is useful, remains unknown. Therefore, the present study was undertaken with the following aim. Aim: To investigate the differences in clinical presentation and disease activity between nr-axSpA and AS. Materials and Methods: A cross sectional study was conducted in Division of Rheumatology, Banaras Hindu University, Varanasi, India from January 2016 to June 2017. All the patients presenting with history of chronic back pain for ≥3 months and age at onset ≤45 years after taking written informed consent were included in the study. Using the ASAS criteria, patients were then classified into two groups of 50 patients each, patients having AS (if there was sacroilitis on radiographs as defined in modified New York criteria) and nr-axSpA diagnosed using ASAS criteria. The various SpA related variables were then compared including gender, age, duration of illness, enthesitis, dactylitis, uveitis, peripheral arthritis, psoriasis, family history, Human Leucocyte Antigen (HLA) B27 positivity, baseline C-Reactive Protein (CRP), baseline Erythrocyte Sedimentation Rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Results: Patients with AS, as compared with nr-axSpA had a longer disease duration {4.5(1.875-8.250) vs. 2.0(1.000- 4.000); p-value 0.023} and had a significantly higher levels of objective markers of inflammation i.e., CRP {4.7(2.325-6.525) vs. 2.20(0.588-4.125); p-value<0.001)} and ESR {(41.98±16.936 vs. 34.20±14.552; p-value 0.015)}. No statistically significant difference was found in age of onset, male: female ratio, enthesitis, dactylitis, uveitis, peripheral arthritis, psoriasis, family history and HLAB27 positivity. Neither any statistically significant difference was noted between the mean BASDAI and BASFI in the two groups. Conclusion: Other than elevated levels of markers of inflammation (CRP/ESR) and a longer disease duration in AS, most other features do not vary significantly between the two groups. Thus, the two groups might represent same disease in different phases.https://jcdr.net/articles/PDF/11493/35982_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PFA(AJ_SL)_PB(AJ_SL)_PN(SL).pdfbackachehuman leucocyte antigen b-27sacroilitis |
| spellingShingle | Uday Prabhakar Anup Singh Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study Journal of Clinical and Diagnostic Research backache human leucocyte antigen b-27 sacroilitis |
| title | Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study |
| title_full | Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study |
| title_fullStr | Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study |
| title_full_unstemmed | Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study |
| title_short | Comparison of Patients with Ankylosing Spondylitis and Non-radiographic Axial Spondyloarthritis-A Cross Sectional Study |
| title_sort | comparison of patients with ankylosing spondylitis and non radiographic axial spondyloarthritis a cross sectional study |
| topic | backache human leucocyte antigen b-27 sacroilitis |
| url | https://jcdr.net/articles/PDF/11493/35982_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PFA(AJ_SL)_PB(AJ_SL)_PN(SL).pdf |
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