Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis
Abstract Background Photodynamic therapy (PDT) has been recently proposed as a promising alternative therapy for Denture Stomatitis (DS). The present systematic review and meta-analysis investigated the current available evidence regarding the efficacy of PDT in the management of DS. Materials and m...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-023-03789-z |
| _version_ | 1797349622181527552 |
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| author | Sadeq A. Al-Maweri Mohammed Nasser Alhajj Lamyia Anweigi Sajna Ashraf Esam Halboub Nosizana Mohd Salleh Rawan H. Alanazi Mohammad Zakaria Nassani Mohammed Noushad Jumma O. Al Khabuli Anas Shamala |
| author_facet | Sadeq A. Al-Maweri Mohammed Nasser Alhajj Lamyia Anweigi Sajna Ashraf Esam Halboub Nosizana Mohd Salleh Rawan H. Alanazi Mohammad Zakaria Nassani Mohammed Noushad Jumma O. Al Khabuli Anas Shamala |
| author_sort | Sadeq A. Al-Maweri |
| collection | DOAJ |
| description | Abstract Background Photodynamic therapy (PDT) has been recently proposed as a promising alternative therapy for Denture Stomatitis (DS). The present systematic review and meta-analysis investigated the current available evidence regarding the efficacy of PDT in the management of DS. Materials and methods PubMed, Scopus, Web of Science, Google Scholar, and ProQuest were searched up to June 7, 2023. All relevant clinical trials were included. RevMan software was used for the statistical analyses. Results Elven randomized clinical trials (460 DS patients) were included. Eight studies assessed the efficacy of PDT vs. topical antifungal therapy, while three studies assessed the adjunctive use of PDT (PDT + antifungal therapy) vs. topical antifungal therapy alone. The results revealed comparable efficacy of PDT and conventional antifungal therapy on candida colonization at 15 days (MD: 0.95, 95% CI: -0.28, 2.19, p = 0.13) and at the end of follow-up (MD: -0.17, 95% CI: -1.33, 0.98, p = 0.77). The pooled two studies revealed relatively better efficacy of adjunctive use of PDT with antifungal therapy on candida colonization compared to antifungal therapy alone at 15 days (MD: -6.67, 95% CI: -15.15, 1.82, p = 0.12), and at the end of follow-up (MD: -7.14, 95% CI: -19.78, 5.50, p = 0.27). Additionally, the results revealed comparable efficacy of PDT and topical antifungal therapy on the clinical outcomes. Conclusions PDT might be considered a viable option for DS either as an adjunct or as an alternative to the topical antifungal medications. Further studies with adequate sample sizes and standardized PDT parameters are warranted. |
| first_indexed | 2024-03-08T12:32:58Z |
| format | Article |
| id | doaj.art-0843d7de1e744f199b6506b896aadef3 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-08T12:32:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-0843d7de1e744f199b6506b896aadef32024-01-21T12:38:11ZengBMCBMC Oral Health1472-68312024-01-0124111310.1186/s12903-023-03789-zEfficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysisSadeq A. Al-Maweri0Mohammed Nasser Alhajj1Lamyia Anweigi2Sajna Ashraf3Esam Halboub4Nosizana Mohd Salleh5Rawan H. Alanazi6Mohammad Zakaria Nassani7Mohammed Noushad8Jumma O. Al Khabuli9Anas Shamala10College of Dental Medicine, QU Health, Qatar UniversityDepartment of Restorative Dentistry, Faculty of Dentistry, Federal Territory of Kuala Lumpur, Universiti MalayaCollege of Dental Medicine, QU Health, Qatar UniversityDepartment of Oral Medicine and Diagnostic Sciences, Vision CollegesDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan UniversityDepartment of Restorative Dentistry, Faculty of Dentistry, Federal Territory of Kuala Lumpur, Universiti MalayaDepartment of Department of Oral and Maxillofacial Surgery, Vision College of Dentistry and NursingDepartment of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom UniversityDepartment of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom UniversityCollege of Dental Medicine, QU Health, Qatar UniversityDepartment of Preventive and Biomedical Science, College of Dentistry, University of Science & TechnologyAbstract Background Photodynamic therapy (PDT) has been recently proposed as a promising alternative therapy for Denture Stomatitis (DS). The present systematic review and meta-analysis investigated the current available evidence regarding the efficacy of PDT in the management of DS. Materials and methods PubMed, Scopus, Web of Science, Google Scholar, and ProQuest were searched up to June 7, 2023. All relevant clinical trials were included. RevMan software was used for the statistical analyses. Results Elven randomized clinical trials (460 DS patients) were included. Eight studies assessed the efficacy of PDT vs. topical antifungal therapy, while three studies assessed the adjunctive use of PDT (PDT + antifungal therapy) vs. topical antifungal therapy alone. The results revealed comparable efficacy of PDT and conventional antifungal therapy on candida colonization at 15 days (MD: 0.95, 95% CI: -0.28, 2.19, p = 0.13) and at the end of follow-up (MD: -0.17, 95% CI: -1.33, 0.98, p = 0.77). The pooled two studies revealed relatively better efficacy of adjunctive use of PDT with antifungal therapy on candida colonization compared to antifungal therapy alone at 15 days (MD: -6.67, 95% CI: -15.15, 1.82, p = 0.12), and at the end of follow-up (MD: -7.14, 95% CI: -19.78, 5.50, p = 0.27). Additionally, the results revealed comparable efficacy of PDT and topical antifungal therapy on the clinical outcomes. Conclusions PDT might be considered a viable option for DS either as an adjunct or as an alternative to the topical antifungal medications. Further studies with adequate sample sizes and standardized PDT parameters are warranted.https://doi.org/10.1186/s12903-023-03789-zPhotodynamic therapyDenture stomatitisManagementSystematic review |
| spellingShingle | Sadeq A. Al-Maweri Mohammed Nasser Alhajj Lamyia Anweigi Sajna Ashraf Esam Halboub Nosizana Mohd Salleh Rawan H. Alanazi Mohammad Zakaria Nassani Mohammed Noushad Jumma O. Al Khabuli Anas Shamala Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis BMC Oral Health Photodynamic therapy Denture stomatitis Management Systematic review |
| title | Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis |
| title_full | Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis |
| title_fullStr | Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis |
| title_short | Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis |
| title_sort | efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis a systematic review and meta analysis |
| topic | Photodynamic therapy Denture stomatitis Management Systematic review |
| url | https://doi.org/10.1186/s12903-023-03789-z |
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