Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period. The age of patients is tending younger, and the racial difference is large. It is also related to family hist...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-08-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1463 |
| _version_ | 1827857126498762752 |
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| author | ZHANG Lijia LIU Jiarui ZHANG Yuan CHEN Xinyu WANG Xin ZHANG Yi |
| author_facet | ZHANG Lijia LIU Jiarui ZHANG Yuan CHEN Xinyu WANG Xin ZHANG Yi |
| author_sort | ZHANG Lijia |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period. The age of patients is tending younger, and the racial difference is large. It is also related to family history, and genetic susceptibility is obvious. So, elucidating the genetic risk factors of TNBC and obtaining precise therapeutic targets are urgent tasks. Obtaining reliable characteristic genes and their polymorphisms between TNBC of different subtypes is difficult. This review summarizes the susceptibility genes and the polymorphisms of TNBC susceptibility genes of different molecular subtypes, in order to develop effective TNBC prevention strategies and find effective therapeutic targets. This review provides a theoretical basis for promoting the study of TNBC from the perspective of genetics. |
| first_indexed | 2024-03-12T12:35:53Z |
| format | Article |
| id | doaj.art-0845e0957a204a15989f74e99c491274 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-12T12:35:53Z |
| publishDate | 2023-08-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-0845e0957a204a15989f74e99c4912742023-08-29T03:05:06ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-08-0150879479910.3971/j.issn.1000-8578.2023.22.14638578.2023.22.1463Research Progress on Genetic Susceptibility to Triple-Negative Breast CancerZHANG Lijia0LIU Jiarui1ZHANG Yuan2CHEN Xinyu3WANG Xin4ZHANG Yi5Public Health College, Zunyi Medical University, Zunyi 563000, ChinaPublic Health College, Zunyi Medical University, Zunyi 563000, ChinaPublic Health College, Zunyi Medical University, Zunyi 563000, ChinaPublic Health College, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaPublic Health College, Zunyi Medical University, Zunyi 563000, ChinaTriple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period. The age of patients is tending younger, and the racial difference is large. It is also related to family history, and genetic susceptibility is obvious. So, elucidating the genetic risk factors of TNBC and obtaining precise therapeutic targets are urgent tasks. Obtaining reliable characteristic genes and their polymorphisms between TNBC of different subtypes is difficult. This review summarizes the susceptibility genes and the polymorphisms of TNBC susceptibility genes of different molecular subtypes, in order to develop effective TNBC prevention strategies and find effective therapeutic targets. This review provides a theoretical basis for promoting the study of TNBC from the perspective of genetics.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1463triple-negative breast cancerepidemic profilesusceptibility genesgenetic polymorphismbiomarker |
| spellingShingle | ZHANG Lijia LIU Jiarui ZHANG Yuan CHEN Xinyu WANG Xin ZHANG Yi Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer Zhongliu Fangzhi Yanjiu triple-negative breast cancer epidemic profile susceptibility genes genetic polymorphism biomarker |
| title | Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer |
| title_full | Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer |
| title_fullStr | Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer |
| title_full_unstemmed | Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer |
| title_short | Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer |
| title_sort | research progress on genetic susceptibility to triple negative breast cancer |
| topic | triple-negative breast cancer epidemic profile susceptibility genes genetic polymorphism biomarker |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1463 |
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