Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation

Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation

Abstract Diabetic ulcers, a difficult problem faced by clinicians, are strongly associated with an increase in cellular senescence. Few empirical studies have focused on exploring a targeted strategy to cure diabetic wounds by eliminating senescent fibroblasts (SFs) and reducing side effects. In thi...

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Bibliographic Details
Main Authors: Renliang Zhao, Xiangyun Jin, Ang Li, Bitong Xu, Yifan Shen, Wei Wang, Jinghuan Huang, Yadong Zhang, Xiaolin Li
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Advanced Science
Subjects:
diabetic wound healing
DPP4 receptor
nanospheres
selective targeting
senescence
Online Access:https://doi.org/10.1002/advs.202104128

Internet

https://doi.org/10.1002/advs.202104128

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