Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review
This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-04-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241242582 |
| _version_ | 1797213499692154880 |
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| author | Ole Oelerich Linda Daume Negin Yekkalam Marcel Hanisch Max C. Menne |
| author_facet | Ole Oelerich Linda Daume Negin Yekkalam Marcel Hanisch Max C. Menne |
| author_sort | Ole Oelerich |
| collection | DOAJ |
| description | This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations have been identified in genes that impact the production or assembly of collagen for all subtypes except hEDS. While the correlation between GJH and TMD has been analysed in various studies, fewer studies have examined TMD in patients with EDS, with most showing an increased prevalence of TMD. In case–control studies, an elevated prevalence of myalgia, arthralgia and disc-related disorders was found in individuals with EDS. Various therapeutic interventions have been reported within the literature in the form of case reports and observational studies, but there are no long-term clinical trials with results on the efficacy of different therapeutic approaches to date. This review demonstrates the high prevalence of different TMDs in different subtypes of EDS, but also shows that little is known about the success of treatment thus far. Further clinical research is necessary to provide adequate guidance on targeted treatment. |
| first_indexed | 2024-04-24T10:59:15Z |
| format | Article |
| id | doaj.art-0849f63a9f9d415fa53b0f9ddae8fc88 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-24T10:59:15Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-0849f63a9f9d415fa53b0f9ddae8fc882024-04-12T03:03:34ZengSAGE PublishingJournal of International Medical Research1473-23002024-04-015210.1177/03000605241242582Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative reviewOle OelerichLinda DaumeNegin YekkalamMarcel HanischMax C. MenneThis narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations have been identified in genes that impact the production or assembly of collagen for all subtypes except hEDS. While the correlation between GJH and TMD has been analysed in various studies, fewer studies have examined TMD in patients with EDS, with most showing an increased prevalence of TMD. In case–control studies, an elevated prevalence of myalgia, arthralgia and disc-related disorders was found in individuals with EDS. Various therapeutic interventions have been reported within the literature in the form of case reports and observational studies, but there are no long-term clinical trials with results on the efficacy of different therapeutic approaches to date. This review demonstrates the high prevalence of different TMDs in different subtypes of EDS, but also shows that little is known about the success of treatment thus far. Further clinical research is necessary to provide adequate guidance on targeted treatment.https://doi.org/10.1177/03000605241242582 |
| spellingShingle | Ole Oelerich Linda Daume Negin Yekkalam Marcel Hanisch Max C. Menne Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review Journal of International Medical Research |
| title | Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review |
| title_full | Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review |
| title_fullStr | Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review |
| title_full_unstemmed | Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review |
| title_short | Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review |
| title_sort | temporomandibular disorders among ehlers danlos syndromes a narrative review |
| url | https://doi.org/10.1177/03000605241242582 |
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