FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

<p>Androgenetic alopecia (AGA) is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT), which can lead to miniaturizati...

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Bibliographic Details
Main Authors: Ni Komang Tristiana Dewi, I Wyn. Sugiritama
Format: Article
Language:English
Published: Universitas Udayana 2013-04-01
Series:e-Jurnal Medika Udayana
Subjects:
Online Access:http://ojs.unud.ac.id/index.php/eum/article/view/5109
Description
Summary:<p>Androgenetic alopecia (AGA) is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT), which can lead to miniaturization of the hair follicle. Finasteride is one of drugs that proven effective in treating hair loss caused by AGA. Finasteride is a 4-azasteroid components that are competitive and specific inhibitor of the enzyme 5-?-reductase type II, an enzyme that converts testosteron into intracellular DHT. By inhibiting the enzyme 5-?-reductase type II, conversion of testosteron to DHT inhibited, thereby causing a significant decrease in serum and tissue DHT concentrations. The use of finasteride 1 mg per day proven to effectively treat AGA in men.</p> <p> </p>
ISSN:2303-1395