High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion
Development of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5002 |
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| author | Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández |
| author_facet | Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández |
| author_sort | Ricardo Rivera-López |
| collection | DOAJ |
| description | Development of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients undergoing percutaneous coronary intervention (PCI) for chronic coronary total occlusion (CTO) and its association with radiation dose. The study analyzed the incidence of cataracts during the follow-up of 126 patients who underwent chronic total coronary PCI, using Cox regression to identify predictive factors of cataract development. The study included 126 patients, 86.9% male, with a mean age of 60.5 years (range, 55.0–68.0 years). Twenty-three (18.2% <i>n</i> = 23) developed cataracts during a mean follow-up of 49.5 months (range 37.3–64.5 months). A higher incidence was observed in patients who received more than 5 Gy (29.0% vs. 14.7%, Hazard ratio (HR = 2.84 [1.19–6.77]). Multivariate analysis revealed a relationship between cataract development during the follow-up and a receipt of radiation dose >5 Gy (HR = 2.60, 95% confidence interval [CI 1.03–6.61]; <i>p</i> = 0.03), presence or history of predisposing eye disease (HR = 4.42, CI:1.57–12.40), diabetes (HR = 3.33 [1.22–9.24]), and older age, as in >57 (HR, 6.40 [1.81–22.61]). An elevated incidence of cataracts was observed in patients after PCI for CTO. The onset of cataracts is related to the radiation dose during catheterization, which is a potentially avoidable effect of which operators should be aware. |
| first_indexed | 2024-03-10T05:59:21Z |
| format | Article |
| id | doaj.art-084c2bbfe1494261aaad7ddabd591c11 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:59:21Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-084c2bbfe1494261aaad7ddabd591c112023-11-22T21:05:55ZengMDPI AGJournal of Clinical Medicine2077-03832021-10-011021500210.3390/jcm10215002High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total OcclusionRicardo Rivera-López0Celia García-López1José M. Sánchez-Moreno2Rafael A. Rivera-López3Julio Almansa-López4Ricardo Rivera-Fernández5Eduardo Molina-Navarro6Miriam Jiménez-Fernández7Santiago Ortiz-Pérez8José A. Ramírez-Hernández9Cardiology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainDepartment of Ophtalmology, University Hospital Virgen de las Nieves, Av. de las Fuerzas Armadas, 2, 18014 Granada, SpainCardiology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainUniversity of Granada (UGR), 18016 Granada, SpainRadiophysics Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainIntensive Care Department, University Hospital of Jaén, 23007 Jaén, SpainCardiology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainCardiology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainBiosanitary Research Institute ibs.GRANADA, 18012 Granada, SpainCardiology Department, Virgen de las Nieves University Hospital, 18014 Granada, SpainDevelopment of cataracts is a well-known adverse effect of ionizing radiation, but little information is available on their incidence in patients after other medical procedures, such as cardiac catheterizations. The study objective was to determine the incidence of cataracts in a cohort of patients undergoing percutaneous coronary intervention (PCI) for chronic coronary total occlusion (CTO) and its association with radiation dose. The study analyzed the incidence of cataracts during the follow-up of 126 patients who underwent chronic total coronary PCI, using Cox regression to identify predictive factors of cataract development. The study included 126 patients, 86.9% male, with a mean age of 60.5 years (range, 55.0–68.0 years). Twenty-three (18.2% <i>n</i> = 23) developed cataracts during a mean follow-up of 49.5 months (range 37.3–64.5 months). A higher incidence was observed in patients who received more than 5 Gy (29.0% vs. 14.7%, Hazard ratio (HR = 2.84 [1.19–6.77]). Multivariate analysis revealed a relationship between cataract development during the follow-up and a receipt of radiation dose >5 Gy (HR = 2.60, 95% confidence interval [CI 1.03–6.61]; <i>p</i> = 0.03), presence or history of predisposing eye disease (HR = 4.42, CI:1.57–12.40), diabetes (HR = 3.33 [1.22–9.24]), and older age, as in >57 (HR, 6.40 [1.81–22.61]). An elevated incidence of cataracts was observed in patients after PCI for CTO. The onset of cataracts is related to the radiation dose during catheterization, which is a potentially avoidable effect of which operators should be aware.https://www.mdpi.com/2077-0383/10/21/5002cataractsionizing radiationchronic coronary total occlusionpercutaneous coronary intervention |
| spellingShingle | Ricardo Rivera-López Celia García-López José M. Sánchez-Moreno Rafael A. Rivera-López Julio Almansa-López Ricardo Rivera-Fernández Eduardo Molina-Navarro Miriam Jiménez-Fernández Santiago Ortiz-Pérez José A. Ramírez-Hernández High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion Journal of Clinical Medicine cataracts ionizing radiation chronic coronary total occlusion percutaneous coronary intervention |
| title | High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion |
| title_full | High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion |
| title_fullStr | High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion |
| title_full_unstemmed | High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion |
| title_short | High Incidence of Cataracts in the Follow-Up of Patients Undergoing Percutaneous Coronary Intervention for Chronic Coronary Total Occlusion |
| title_sort | high incidence of cataracts in the follow up of patients undergoing percutaneous coronary intervention for chronic coronary total occlusion |
| topic | cataracts ionizing radiation chronic coronary total occlusion percutaneous coronary intervention |
| url | https://www.mdpi.com/2077-0383/10/21/5002 |
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