Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal...
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| author | William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena |
| author_facet | William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena |
| author_sort | William M. de Souza |
| collection | DOAJ |
| description | A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, <i>n</i> = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, <i>n</i> = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly. |
| first_indexed | 2024-03-10T04:58:47Z |
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| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:58:47Z |
| publishDate | 2021-10-01 |
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| series | Viruses |
| spelling | doaj.art-084c74eea275456eb320f5f7c03ed4f62023-11-23T01:55:16ZengMDPI AGViruses1999-49152021-10-011311212710.3390/v13112127Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated VaccinesWilliam M. de Souza0Stéfanie P. Muraro1Gabriela F. Souza2Mariene R. Amorim3Renata Sesti-Costa4Luciana S. Mofatto5Julia Forato6Priscilla P. Barbosa7Daniel A. Toledo-Teixeira8Karina Bispo-dos-Santos9Pierina L. Parise10Natalia S. Brunetti11Joselia C. O. Moreira12Vitor A. Costa13Daniela M. Cardozo14Maria L. Moretti15Silvia Barros-Mazon16Gabriela F. Marchesi17Christiane Ambrosio18Fernando R. Spilki19Valeria C. Almeida20Andre S. Vieira21Lair Zambon22Alessandro S. Farias23Marcelo Addas-Carvalho24Bruno D. Benites25Rafael E. Marques26Ester C. Sabino27Andrea B. Von Zuben28Scott C. Weaver29Nuno R. Faria30Fabiana Granja31Rodrigo N. Angerami32José Luiz Proença-Módena33Virology Research Centre, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilBrazilian Biosciences National Laboratory, Brazilian Centre for Research in Energy and Materials, Campinas 13083-100, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilAutoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilHematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, BrazilDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas 13083-862, BrazilDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, BrazilDepartment of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas 13083-862, BrazilCampinas Department of Public Health Surveillance, Campinas 13015-904, BrazilCampinas Department of Public Health Surveillance, Campinas 13015-904, BrazilOne Health Laboratory, Feevale University, Novo Hamburgo 93510-235, BrazilCampinas Department of Public Health Surveillance, Campinas 13015-904, BrazilDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, BrazilAutoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilHematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, BrazilHematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, BrazilBrazilian Biosciences National Laboratory, Brazilian Centre for Research in Energy and Materials, Campinas 13083-100, BrazilTropical Medicine Institute, Medical School, University of São Paulo, São Paulo 05403-907, BrazilCampinas Department of Public Health Surveillance, Campinas 13015-904, BrazilDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo 05403-000, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, BrazilLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, BrazilA SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, <i>n</i> = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, <i>n</i> = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly.https://www.mdpi.com/1999-4915/13/11/2127SARS-CoV-2COVID-19variant of concernB.1.1.7vaccineoutbreak |
| spellingShingle | William M. de Souza Stéfanie P. Muraro Gabriela F. Souza Mariene R. Amorim Renata Sesti-Costa Luciana S. Mofatto Julia Forato Priscilla P. Barbosa Daniel A. Toledo-Teixeira Karina Bispo-dos-Santos Pierina L. Parise Natalia S. Brunetti Joselia C. O. Moreira Vitor A. Costa Daniela M. Cardozo Maria L. Moretti Silvia Barros-Mazon Gabriela F. Marchesi Christiane Ambrosio Fernando R. Spilki Valeria C. Almeida Andre S. Vieira Lair Zambon Alessandro S. Farias Marcelo Addas-Carvalho Bruno D. Benites Rafael E. Marques Ester C. Sabino Andrea B. Von Zuben Scott C. Weaver Nuno R. Faria Fabiana Granja Rodrigo N. Angerami José Luiz Proença-Módena Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines Viruses SARS-CoV-2 COVID-19 variant of concern B.1.1.7 vaccine outbreak |
| title | Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines |
| title_full | Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines |
| title_fullStr | Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines |
| title_full_unstemmed | Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines |
| title_short | Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines |
| title_sort | clusters of sars cov 2 lineage b 1 1 7 infection after vaccination with adenovirus vectored and inactivated vaccines |
| topic | SARS-CoV-2 COVID-19 variant of concern B.1.1.7 vaccine outbreak |
| url | https://www.mdpi.com/1999-4915/13/11/2127 |
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