Role of CRP as a marker for discrimination of exudative and transudative pleural effusion
Differentiation between exudative and transudative pleural effusion is sometime problematic. This study aimed to evaluate the diagnostic value of C-reactive protein (CRP) in differentiation of exudative and transudative pleural effusion. This is an analytical epidemiologic cross-sectional study tha...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-03-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/2059 |
| _version_ | 1819023752869969920 |
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| author | Omid Rismantab Seyed Aili Javad Moosavi Mohammad Reza Farahnak Maryam Dastoorpoor Hanieh Raji |
| author_facet | Omid Rismantab Seyed Aili Javad Moosavi Mohammad Reza Farahnak Maryam Dastoorpoor Hanieh Raji |
| author_sort | Omid Rismantab |
| collection | DOAJ |
| description |
Differentiation between exudative and transudative pleural effusion is sometime problematic. This study aimed to evaluate the diagnostic value of C-reactive protein (CRP) in differentiation of exudative and transudative pleural effusion. This is an analytical epidemiologic cross-sectional study that evaluates the role of CRP in differentiating transudative and exudative pleural effusion. Patients were divided into two groups of exudates and transudates, based on Light’s criteria. The pleural effusion CRP levels were compared between the two groups. SPSS software version 16 was used for statistical analysis. The significance level was considered p<0.05. A total of 169 patients with pleural effusion enrolled in the study. Based on Light's criteria, 108 patients (63.9%) had exudative pleural effusion and 61 (36.1%) had transudative pleural effusion. The level of CRP in the pleural fluid of patients in the exudative and transudative groups was 13.3±37.1 and 3.5±4.3mg/dl, respectively (p=0.008). The 3.31 mg/dl cut-off point of CRP level of pleural effusion had the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 72.1%, 86% and 91.7% respectively. The results obtained in our study shows that the level of CRP in the effusion fluid can be helpful in differentiating exudative from transudative pleural effusions.
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| first_indexed | 2024-12-21T04:43:54Z |
| format | Article |
| id | doaj.art-084cf1e0ecc74c058293dec19ad4c1f5 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-21T04:43:54Z |
| publishDate | 2022-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-084cf1e0ecc74c058293dec19ad4c1f52022-12-21T19:15:36ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642022-03-0110.4081/monaldi.2022.2059Role of CRP as a marker for discrimination of exudative and transudative pleural effusionOmid Rismantab0Seyed Aili Javad Moosavi1Mohammad Reza Farahnak2Maryam Dastoorpoor3Hanieh Raji4Department of Internal Medicine, Air pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, AhvazAir Pollution Research Center, Iran University of Medical Sciences, TehranThoracic Surgery Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, AhvazDepartment of Internal Medicine, Air pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Differentiation between exudative and transudative pleural effusion is sometime problematic. This study aimed to evaluate the diagnostic value of C-reactive protein (CRP) in differentiation of exudative and transudative pleural effusion. This is an analytical epidemiologic cross-sectional study that evaluates the role of CRP in differentiating transudative and exudative pleural effusion. Patients were divided into two groups of exudates and transudates, based on Light’s criteria. The pleural effusion CRP levels were compared between the two groups. SPSS software version 16 was used for statistical analysis. The significance level was considered p<0.05. A total of 169 patients with pleural effusion enrolled in the study. Based on Light's criteria, 108 patients (63.9%) had exudative pleural effusion and 61 (36.1%) had transudative pleural effusion. The level of CRP in the pleural fluid of patients in the exudative and transudative groups was 13.3±37.1 and 3.5±4.3mg/dl, respectively (p=0.008). The 3.31 mg/dl cut-off point of CRP level of pleural effusion had the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 72.1%, 86% and 91.7% respectively. The results obtained in our study shows that the level of CRP in the effusion fluid can be helpful in differentiating exudative from transudative pleural effusions. https://www.monaldi-archives.org/index.php/macd/article/view/2059CRP, pleural effusion, exudate, transudate |
| spellingShingle | Omid Rismantab Seyed Aili Javad Moosavi Mohammad Reza Farahnak Maryam Dastoorpoor Hanieh Raji Role of CRP as a marker for discrimination of exudative and transudative pleural effusion Monaldi Archives for Chest Disease CRP, pleural effusion, exudate, transudate |
| title | Role of CRP as a marker for discrimination of exudative and transudative pleural effusion |
| title_full | Role of CRP as a marker for discrimination of exudative and transudative pleural effusion |
| title_fullStr | Role of CRP as a marker for discrimination of exudative and transudative pleural effusion |
| title_full_unstemmed | Role of CRP as a marker for discrimination of exudative and transudative pleural effusion |
| title_short | Role of CRP as a marker for discrimination of exudative and transudative pleural effusion |
| title_sort | role of crp as a marker for discrimination of exudative and transudative pleural effusion |
| topic | CRP, pleural effusion, exudate, transudate |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/2059 |
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