HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis
BackgroundAlthough the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR is upregulated and associated with poor prognosis for some tumors.MethodsExploring HMMR expression in different tumor types using The Cancer Genome Atlas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.998598/full |
| _version_ | 1797956418888794112 |
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| author | Junyi Shang Xiaoju Zhang Guangjie Hou Yong Qi |
| author_facet | Junyi Shang Xiaoju Zhang Guangjie Hou Yong Qi |
| author_sort | Junyi Shang |
| collection | DOAJ |
| description | BackgroundAlthough the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR is upregulated and associated with poor prognosis for some tumors.MethodsExploring HMMR expression in different tumor types using The Cancer Genome Atlas (TCGA) or other public databases for a pan-cancer analysis, exploring the relationship between HMMR and tumor prognosis, and exploring the role of HMMR in tumor immunity.ResultsNo matter the pairing or unpairing of data, HMMR expression generally increased compared to corresponding normal tissue. Based on a CCLE study, our results indicated that HMMR is widely expressed in various tumor cells. For most tumor types, high HMMR expression was associated with reduced Overall Survival (OS), Return to Functional Status (RFS), and Platinum Free Interval (PFI). ROC curves indicated that HMMR displays high prediction potential for most tumor types. In pan-cancer, HMMR is correlated with some clinical staging, immune cells, and immune checkpoints for some tumors. The GO/KEGG enrichment analysis results for proteins most closely related to HMMR indicate that the most highly enriched pathways are all related to tumor development.ConclusionsOur pan-cancer analysis of HMMR suggests that HMMR can be used as a potential diagnostic and prognostic indicator of pan-cancer and that HMMR may be involved in tumor development. |
| first_indexed | 2024-04-10T23:48:44Z |
| format | Article |
| id | doaj.art-084e2a95fde84101b3c1f9ce4194ecd2 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-10T23:48:44Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-084e2a95fde84101b3c1f9ce4194ecd22023-01-10T20:34:24ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-01-01910.3389/fsurg.2022.998598998598HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysisJunyi Shang0Xiaoju Zhang1Guangjie Hou2Yong Qi3Department of Respiratory and Critical Care Medicine; Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Respiratory and Critical Care Medicine; Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Thoracic Surgery; Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Respiratory and Critical Care Medicine; Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundAlthough the status of universal upregulation for the Hyaluronan-Mediated Motility Receptor (HMMR) in pan-cancer is still unknown, HMMR is upregulated and associated with poor prognosis for some tumors.MethodsExploring HMMR expression in different tumor types using The Cancer Genome Atlas (TCGA) or other public databases for a pan-cancer analysis, exploring the relationship between HMMR and tumor prognosis, and exploring the role of HMMR in tumor immunity.ResultsNo matter the pairing or unpairing of data, HMMR expression generally increased compared to corresponding normal tissue. Based on a CCLE study, our results indicated that HMMR is widely expressed in various tumor cells. For most tumor types, high HMMR expression was associated with reduced Overall Survival (OS), Return to Functional Status (RFS), and Platinum Free Interval (PFI). ROC curves indicated that HMMR displays high prediction potential for most tumor types. In pan-cancer, HMMR is correlated with some clinical staging, immune cells, and immune checkpoints for some tumors. The GO/KEGG enrichment analysis results for proteins most closely related to HMMR indicate that the most highly enriched pathways are all related to tumor development.ConclusionsOur pan-cancer analysis of HMMR suggests that HMMR can be used as a potential diagnostic and prognostic indicator of pan-cancer and that HMMR may be involved in tumor development.https://www.frontiersin.org/articles/10.3389/fsurg.2022.998598/fullHMMRpan-cancerprognosisimmune infiltrationTCGA |
| spellingShingle | Junyi Shang Xiaoju Zhang Guangjie Hou Yong Qi HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis Frontiers in Surgery HMMR pan-cancer prognosis immune infiltration TCGA |
| title | HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis |
| title_full | HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis |
| title_fullStr | HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis |
| title_full_unstemmed | HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis |
| title_short | HMMR potential as a diagnostic and prognostic biomarker of cancer—speculation based on a pan-cancer analysis |
| title_sort | hmmr potential as a diagnostic and prognostic biomarker of cancer speculation based on a pan cancer analysis |
| topic | HMMR pan-cancer prognosis immune infiltration TCGA |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.998598/full |
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