Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety
In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of d...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2013-09-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2580 |
| _version_ | 1818056183750066176 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids were dehydrated in the third step via treatment with acetic anhydride and anhydrous sodium acetate to afford a series of the desirable N-(substituted benzothiazole -2-yl) maleimides.The synthesized maleimides were screened for thier antibacterial activity against two types of bacteria including (staphylococcus aureus) Gram positive and (Klebsiella pneumoniae) Gram negative bacteria respectively.Antifungal activity of the prepared imides also were tested against (Candida albicans) fungi.The new compounds were found to exhibit good antibacterial and antifungal activities. |
| first_indexed | 2024-12-10T12:24:48Z |
| format | Article |
| id | doaj.art-084f3245ef384d4d99195dcb3f733006 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-10T12:24:48Z |
| publishDate | 2013-09-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-084f3245ef384d4d99195dcb3f7330062022-12-22T01:48:59ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862013-09-0110310.21123/bsj.10.3.658-672Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moietyBaghdad Science JournalIn this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids were dehydrated in the third step via treatment with acetic anhydride and anhydrous sodium acetate to afford a series of the desirable N-(substituted benzothiazole -2-yl) maleimides.The synthesized maleimides were screened for thier antibacterial activity against two types of bacteria including (staphylococcus aureus) Gram positive and (Klebsiella pneumoniae) Gram negative bacteria respectively.Antifungal activity of the prepared imides also were tested against (Candida albicans) fungi.The new compounds were found to exhibit good antibacterial and antifungal activities.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2580Synthesis ,Antimicrobial activity , Maleimides Benzothiazole |
| spellingShingle | Baghdad Science Journal Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety Baghdad Science Journal Synthesis ,Antimicrobial activity , Maleimides Benzothiazole |
| title | Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety |
| title_full | Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety |
| title_fullStr | Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety |
| title_full_unstemmed | Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety |
| title_short | Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety |
| title_sort | synthesis and evaluation of antimicrobial activity of several new maleimides to benzothiazole moiety |
| topic | Synthesis ,Antimicrobial activity , Maleimides Benzothiazole |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2580 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandevaluationofantimicrobialactivityofseveralnewmaleimidestobenzothiazolemoiety |