Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide
Aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H<sub>2<...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/1/372 |
| Summary: | Aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H<sub>2</sub>O<sub>2</sub> permeability by modulating AQPs. To further analyze the action of nanoparticles (NPs) on AQP, we examined the effect of the NPs presenting different core compositions (CeO<sub>2</sub>, Gd<sub>2</sub>O<sub>3</sub>, Fe<sub>3</sub>O<sub>4</sub>, and TiO<sub>2</sub>), hydrodynamic sizes, and surface functionalization. The NPs produced an increase in H<sub>2</sub>O and H<sub>2</sub>O<sub>2</sub> permeability as a general trend. The hydrodynamic sizes of the NPs in the range of 22–100 nm did not produce any significant effect. The chemical nature of the NPs’ core did not modify the effect and its intensity. On the other hand, the NPs’ functionalized surface plays a major role in influencing both water and H<sub>2</sub>O<sub>2</sub> permeability. The results suggest that NPs can play a significant role in controlling oxidative stress in cells and might represent an innovative approach in the treatment of a number of pathologies associated with an increased oxidative status. |
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| ISSN: | 1661-6596 1422-0067 |