Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide
Aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H<sub>2<...
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/372 |
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| author | Giorgia Pellavio Maria Paola Demichelis Patrizia Sommi Umberto Anselmi-Tamburini Claudia Scotti Umberto Laforenza |
| author_facet | Giorgia Pellavio Maria Paola Demichelis Patrizia Sommi Umberto Anselmi-Tamburini Claudia Scotti Umberto Laforenza |
| author_sort | Giorgia Pellavio |
| collection | DOAJ |
| description | Aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H<sub>2</sub>O<sub>2</sub> permeability by modulating AQPs. To further analyze the action of nanoparticles (NPs) on AQP, we examined the effect of the NPs presenting different core compositions (CeO<sub>2</sub>, Gd<sub>2</sub>O<sub>3</sub>, Fe<sub>3</sub>O<sub>4</sub>, and TiO<sub>2</sub>), hydrodynamic sizes, and surface functionalization. The NPs produced an increase in H<sub>2</sub>O and H<sub>2</sub>O<sub>2</sub> permeability as a general trend. The hydrodynamic sizes of the NPs in the range of 22–100 nm did not produce any significant effect. The chemical nature of the NPs’ core did not modify the effect and its intensity. On the other hand, the NPs’ functionalized surface plays a major role in influencing both water and H<sub>2</sub>O<sub>2</sub> permeability. The results suggest that NPs can play a significant role in controlling oxidative stress in cells and might represent an innovative approach in the treatment of a number of pathologies associated with an increased oxidative status. |
| first_indexed | 2024-03-08T15:04:58Z |
| format | Article |
| id | doaj.art-0851edb3a22e4788844a1d492223772a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:04:58Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0851edb3a22e4788844a1d492223772a2024-01-10T14:59:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125137210.3390/ijms25010372Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen PeroxideGiorgia Pellavio0Maria Paola Demichelis1Patrizia Sommi2Umberto Anselmi-Tamburini3Claudia Scotti4Umberto Laforenza5Human Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyDepartment of Chemistry, University of Pavia, 27100 Pavia, ItalyHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyDepartment of Chemistry, University of Pavia, 27100 Pavia, ItalyUnit of Immunology and General Pathology, Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyAquaporins (AQPs) allow the diffusion of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H<sub>2</sub>O<sub>2</sub> permeability by modulating AQPs. To further analyze the action of nanoparticles (NPs) on AQP, we examined the effect of the NPs presenting different core compositions (CeO<sub>2</sub>, Gd<sub>2</sub>O<sub>3</sub>, Fe<sub>3</sub>O<sub>4</sub>, and TiO<sub>2</sub>), hydrodynamic sizes, and surface functionalization. The NPs produced an increase in H<sub>2</sub>O and H<sub>2</sub>O<sub>2</sub> permeability as a general trend. The hydrodynamic sizes of the NPs in the range of 22–100 nm did not produce any significant effect. The chemical nature of the NPs’ core did not modify the effect and its intensity. On the other hand, the NPs’ functionalized surface plays a major role in influencing both water and H<sub>2</sub>O<sub>2</sub> permeability. The results suggest that NPs can play a significant role in controlling oxidative stress in cells and might represent an innovative approach in the treatment of a number of pathologies associated with an increased oxidative status.https://www.mdpi.com/1422-0067/25/1/372HeLaoxidative stresswater channelsperoxiporinHyPer7 biosensorCeO<sub>2</sub>NP |
| spellingShingle | Giorgia Pellavio Maria Paola Demichelis Patrizia Sommi Umberto Anselmi-Tamburini Claudia Scotti Umberto Laforenza Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide International Journal of Molecular Sciences HeLa oxidative stress water channels peroxiporin HyPer7 biosensor CeO<sub>2</sub>NP |
| title | Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide |
| title_full | Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide |
| title_fullStr | Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide |
| title_full_unstemmed | Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide |
| title_short | Polyacrylic-Coated Solid Nanoparticles Increase the Aquaporin Permeability to Hydrogen Peroxide |
| title_sort | polyacrylic coated solid nanoparticles increase the aquaporin permeability to hydrogen peroxide |
| topic | HeLa oxidative stress water channels peroxiporin HyPer7 biosensor CeO<sub>2</sub>NP |
| url | https://www.mdpi.com/1422-0067/25/1/372 |
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