Origin, evolution and global spread of SARS-CoV-2
SARS-CoV-2 is the virus responsible for the global COVID19 pandemic. We review what is known about the origin of this virus, detected in China at the end of December 2019. The genome of this virus mainly evolves under the effect of point mutations. These are generally neutral and have no impact on v...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2020-11-01
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| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.29/ |
| _version_ | 1827785062502891520 |
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| author | Zhukova, Anna Blassel, Luc Lemoine, Frédéric Morel, Marie Voznica, Jakub Gascuel, Olivier |
| author_facet | Zhukova, Anna Blassel, Luc Lemoine, Frédéric Morel, Marie Voznica, Jakub Gascuel, Olivier |
| author_sort | Zhukova, Anna |
| collection | DOAJ |
| description | SARS-CoV-2 is the virus responsible for the global COVID19 pandemic. We review what is known about the origin of this virus, detected in China at the end of December 2019. The genome of this virus mainly evolves under the effect of point mutations. These are generally neutral and have no impact on virulence and severity, but some appear to influence infectivity, notably the D614G mutation of the Spike protein. To date (30/09/2020) no recombination of the virus has been documented in the human host, and very few insertions and deletions. The worldwide spread of the virus was the subject of controversies that we summarize, before proposing a new approach free from the limitations of previous methods. The results show a complex scenario with, for example, numerous introductions to the USA and returns of the virus from the USA to certain countries including France. |
| first_indexed | 2024-03-11T16:12:49Z |
| format | Article |
| id | doaj.art-08522179c1d34c1cb8a8a3a7697a833b |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:12:49Z |
| publishDate | 2020-11-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-08522179c1d34c1cb8a8a3a7697a833b2023-10-24T14:25:18ZengAcadémie des sciencesComptes Rendus Biologies1768-32382020-11-013441577510.5802/crbiol.2910.5802/crbiol.29Origin, evolution and global spread of SARS-CoV-2Zhukova, Anna0Blassel, Luc1Lemoine, Frédéric2Morel, Marie3Voznica, Jakub4Gascuel, Olivier5Hub de Bioinformatique et Biostatistique, Institut Pasteur, Paris, France; Unité de Bioinformatique Evolutive, Institut Pasteur, Paris, France; Unité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceUnité de Bioinformatique Evolutive, Institut Pasteur, Paris, France; Unité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceHub de Bioinformatique et Biostatistique, Institut Pasteur, Paris, France; Unité de Bioinformatique Evolutive, Institut Pasteur, Paris, France; Unité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceUnité de Bioinformatique Evolutive, Institut Pasteur, Paris, France; Unité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceUnité de Bioinformatique Evolutive, Institut Pasteur, Paris, France; Unité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceUnité de Biologie Computationnelle, USR3756, CNRS, Paris, FranceSARS-CoV-2 is the virus responsible for the global COVID19 pandemic. We review what is known about the origin of this virus, detected in China at the end of December 2019. The genome of this virus mainly evolves under the effect of point mutations. These are generally neutral and have no impact on virulence and severity, but some appear to influence infectivity, notably the D614G mutation of the Spike protein. To date (30/09/2020) no recombination of the virus has been documented in the human host, and very few insertions and deletions. The worldwide spread of the virus was the subject of controversies that we summarize, before proposing a new approach free from the limitations of previous methods. The results show a complex scenario with, for example, numerous introductions to the USA and returns of the virus from the USA to certain countries including France.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.29/SARS-CoV-2COVID19OriginEvolutionTransmissionClusters |
| spellingShingle | Zhukova, Anna Blassel, Luc Lemoine, Frédéric Morel, Marie Voznica, Jakub Gascuel, Olivier Origin, evolution and global spread of SARS-CoV-2 Comptes Rendus Biologies SARS-CoV-2 COVID19 Origin Evolution Transmission Clusters |
| title | Origin, evolution and global spread of SARS-CoV-2 |
| title_full | Origin, evolution and global spread of SARS-CoV-2 |
| title_fullStr | Origin, evolution and global spread of SARS-CoV-2 |
| title_full_unstemmed | Origin, evolution and global spread of SARS-CoV-2 |
| title_short | Origin, evolution and global spread of SARS-CoV-2 |
| title_sort | origin evolution and global spread of sars cov 2 |
| topic | SARS-CoV-2 COVID19 Origin Evolution Transmission Clusters |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.29/ |
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