Tetrandrine inhibits the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via IgA receptor/MAPK/NF-κB signaling pathway

Tetrandrine inhibits the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via IgA receptor/MAPK/NF-κB signaling pathway

Objective: Despite the use of renin-angiotensin system blockade and immunosuppressive drugs, including corticosteroids, the current treatment regimens for Immunoglobulins A nephropathy (IgAN) are severely limited. The proliferation of mesangial cell and deposition of deglycosylated human IgA1 immune...

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Bibliographic Details
Main Authors: Wencheng Xu, Wanci Song, Shuhe Chen, Shanshan Jin, Xue Xue, Jinwen Min, Xiaoqin Wang, Pengtao You
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
tetrandrine
mesangial cells
IgA nephropathy
IgA receptor
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1150829/full

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