Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcin...

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Bibliographic Details
Main Authors: Zhongbo Liu, Liankun Song, Jun Xie, Xue-Ru Wu, Greg E. Gin, Beverly Wang, Edward Uchio, Xiaolin Zi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
Kawain
mTOR
chemoprevention
bladder cancer
Online Access:https://www.mdpi.com/1420-3049/28/4/1666

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