Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma
Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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UiTM Press
2021-03-01
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| Series: | Journal of Clinical and Health Sciences |
| Online Access: | http://myjms.mohe.gov.my/index.php/JCHS/article/view/9829 |
| _version_ | 1797849679364358144 |
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| author | Islam Barkatullah Syed Shamshad Ahmad Kafil Akhtar Tariq Mansoor |
| author_facet | Islam Barkatullah Syed Shamshad Ahmad Kafil Akhtar Tariq Mansoor |
| author_sort | Islam Barkatullah |
| collection | DOAJ |
| description | Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance of serum HER-2/neu concentration with tissue HER-2/neu immunohistochemistry and determine its relationship with various prognostic indicators like age, size of tumour, lymph node status, grade, and stage of tumour. Materials and methods: The preoperative serum samples of 56 clinically and cytologically diagnosed cases of breast carcinoma were taken and postoperative mastectomy specimens were examined for the histologic type, lympho-vascular invasion, stage, and grade of the tumour. Immunohistochemical study of HER-2/neu xpression and HER-2/neu serum biochemistry was studied. Results: Age of the patients ranged from 25-75 years. Twenty-three cases (41.1%) were premenopausal while 33 cases (58.9%) postmenopausal. Forty-seven cases (83.9%) were of the infiltrating ductal carcinoma (NOS) type. Serum positivity for HER-2/neu was noted in 29 (51.8%) cases. Serum HER-2/neu levels showed a positive correlation with increase in tumour size, grade, stage of tumour and lymph node involvement. Serum HER-2/neu positivity was seen in 20 (68.9%) IHC positive patients and 9 (33.3%) IHC negative patients, with a statistically significant correlation (p=0.005). Conclusions: Serum HER-2/neu levels directly correlate with prognostic factors like tumour size, grade, stage of the tumour and lymph node metastasis and can be used as a complimentary tool to tissue HER-2/neu immunohistochemistry. |
| first_indexed | 2024-04-09T18:48:25Z |
| format | Article |
| id | doaj.art-0855e837aa6f457c867e71861733831c |
| institution | Directory Open Access Journal |
| issn | 0127-984X |
| language | English |
| last_indexed | 2024-04-09T18:48:25Z |
| publishDate | 2021-03-01 |
| publisher | UiTM Press |
| record_format | Article |
| series | Journal of Clinical and Health Sciences |
| spelling | doaj.art-0855e837aa6f457c867e71861733831c2023-04-10T07:04:52ZengUiTM PressJournal of Clinical and Health Sciences0127-984X2021-03-0161182410.24191/jchs.v6i1.9829Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast CarcinomaIslam BarkatullahSyed Shamshad AhmadKafil AkhtarTariq Mansoor Introduction: Serum levels of HER-2/neu protein is raised in primary as well as metastatic breast cancer and decreased serum HER-2/neu concentration in patients treated with HER- 2/neu inhibitors like trastuzumab is a good prognostic indicator in metastatic cases. Aims: To evaluate the concordance of serum HER-2/neu concentration with tissue HER-2/neu immunohistochemistry and determine its relationship with various prognostic indicators like age, size of tumour, lymph node status, grade, and stage of tumour. Materials and methods: The preoperative serum samples of 56 clinically and cytologically diagnosed cases of breast carcinoma were taken and postoperative mastectomy specimens were examined for the histologic type, lympho-vascular invasion, stage, and grade of the tumour. Immunohistochemical study of HER-2/neu xpression and HER-2/neu serum biochemistry was studied. Results: Age of the patients ranged from 25-75 years. Twenty-three cases (41.1%) were premenopausal while 33 cases (58.9%) postmenopausal. Forty-seven cases (83.9%) were of the infiltrating ductal carcinoma (NOS) type. Serum positivity for HER-2/neu was noted in 29 (51.8%) cases. Serum HER-2/neu levels showed a positive correlation with increase in tumour size, grade, stage of tumour and lymph node involvement. Serum HER-2/neu positivity was seen in 20 (68.9%) IHC positive patients and 9 (33.3%) IHC negative patients, with a statistically significant correlation (p=0.005). Conclusions: Serum HER-2/neu levels directly correlate with prognostic factors like tumour size, grade, stage of the tumour and lymph node metastasis and can be used as a complimentary tool to tissue HER-2/neu immunohistochemistry.http://myjms.mohe.gov.my/index.php/JCHS/article/view/9829 |
| spellingShingle | Islam Barkatullah Syed Shamshad Ahmad Kafil Akhtar Tariq Mansoor Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma Journal of Clinical and Health Sciences |
| title | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma |
| title_full | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma |
| title_fullStr | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma |
| title_full_unstemmed | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma |
| title_short | Correlation of Serum HER-2/neu Levels with Clinico-Pathological Variables and Tissue Immunohistochemistry in Breast Carcinoma |
| title_sort | correlation of serum her 2 neu levels with clinico pathological variables and tissue immunohistochemistry in breast carcinoma |
| url | http://myjms.mohe.gov.my/index.php/JCHS/article/view/9829 |
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