Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are invol...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.941653/full |
| _version_ | 1798041901555777536 |
|---|---|
| author | Ni Fan Hui Fu Xuchen Feng Yatong Chen Jingyu Wang Yuqi Wu Yuhong Bian Yingpeng Li Yingpeng Li |
| author_facet | Ni Fan Hui Fu Xuchen Feng Yatong Chen Jingyu Wang Yuqi Wu Yuhong Bian Yingpeng Li Yingpeng Li |
| author_sort | Ni Fan |
| collection | DOAJ |
| description | Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are involved in the ten hallmarks of cancer, interestingly, they are also closely associated with aerobic glycolysis. However, the mechanism of this process is non-transparent to date. Demonstrating the mechanism of lncRNAs regulating tumorigenesis and tumor progression through aerobic glycolysis is particularly critical for cancer therapy, and may provide novel therapeutic targets or strategies in cancer treatment. In this review, we discuss the role of lncRNAs and aerobic glycolysis in tumorigenesis and tumor progression, and further explore their interaction, in hope to provide a novel therapeutic target for cancer treatment. |
| first_indexed | 2024-04-11T22:28:03Z |
| format | Article |
| id | doaj.art-085640f051114d8ca3f449f61cc0f4a2 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T22:28:03Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-085640f051114d8ca3f449f61cc0f4a22022-12-22T03:59:36ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-08-01910.3389/fmolb.2022.941653941653Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysisNi Fan0Hui Fu1Xuchen Feng2Yatong Chen3Jingyu Wang4Yuqi Wu5Yuhong Bian6Yingpeng Li7Yingpeng Li8College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCompared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are involved in the ten hallmarks of cancer, interestingly, they are also closely associated with aerobic glycolysis. However, the mechanism of this process is non-transparent to date. Demonstrating the mechanism of lncRNAs regulating tumorigenesis and tumor progression through aerobic glycolysis is particularly critical for cancer therapy, and may provide novel therapeutic targets or strategies in cancer treatment. In this review, we discuss the role of lncRNAs and aerobic glycolysis in tumorigenesis and tumor progression, and further explore their interaction, in hope to provide a novel therapeutic target for cancer treatment.https://www.frontiersin.org/articles/10.3389/fmolb.2022.941653/fulllncRNAsaerobic glycolysistumorigenesistumor progressionenzyme |
| spellingShingle | Ni Fan Hui Fu Xuchen Feng Yatong Chen Jingyu Wang Yuqi Wu Yuhong Bian Yingpeng Li Yingpeng Li Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis Frontiers in Molecular Biosciences lncRNAs aerobic glycolysis tumorigenesis tumor progression enzyme |
| title | Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| title_full | Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| title_fullStr | Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| title_full_unstemmed | Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| title_short | Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| title_sort | long non coding rnas play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis |
| topic | lncRNAs aerobic glycolysis tumorigenesis tumor progression enzyme |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.941653/full |
| work_keys_str_mv | AT nifan longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT huifu longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT xuchenfeng longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT yatongchen longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT jingyuwang longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT yuqiwu longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT yuhongbian longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT yingpengli longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis AT yingpengli longnoncodingrnasplayanimportantregulatoryroleintumorigenesisandtumorprogressionthroughaerobicglycolysis |