Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen
<p>Abstract</p> <p>Background</p> <p>Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this study, we investigated...
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| Format: | Article |
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BMC
2010-07-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/10/359 |
| _version_ | 1818757597921017856 |
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| author | Xing Xiaofang Qu Like Lu Aiping Dong Bin Liu Caiyun Meng Lin Wu Jian Eric Shi Y Shou Chengchao |
| author_facet | Xing Xiaofang Qu Like Lu Aiping Dong Bin Liu Caiyun Meng Lin Wu Jian Eric Shi Y Shou Chengchao |
| author_sort | Xing Xiaofang |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this study, we investigated the prognostic potential of SNCG in colon cancer particularly in the patients with normal carcinoembryonic antigen (CEA) levels.</p> <p>Methods</p> <p>SNCG levels were assessed immunohistochemically in cancer tissues from 229 colon adenocarcinoma patients with a mean follow-up of 44 months. Correlations between SNCG levels and clinicopathologic features, preoperative serum CEA level, and clinical outcome were analyzed statistically using SPSS.</p> <p>Results</p> <p>SNCG levels in colon adenocarcinoma were closely associated with intravascular embolus and tumor recurrence but independent of preoperative serum CEA levels. SNCG expression was an independent prognostic factor of a shorter disease-free survival (DFS) and overall survival (OS) (<it>P </it>< 0.0001). Multivariate analysis revealed that both tissue SNCG and serum CEA were independent prognostic factors of DFS (<it>P </it>= 0.001, <0.0001, respectively) for 170 patients with colon adenocarcinomas. Importantly, SNCG remained a prognostic determinant of DFS and OS (<it>P </it>= 0.001, 0.002) for 97 patients with normal preoperative serum CEA level.</p> <p>Conclusions</p> <p>Our results suggest for the first time that SNCG is a new independent predicator for poor prognosis in patients with colon adenocarcinoma, including those with normal CEA levels. Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma.</p> |
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| format | Article |
| id | doaj.art-085a1a1fa34049d28e087dffda77b3a9 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-18T06:13:28Z |
| publishDate | 2010-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-085a1a1fa34049d28e087dffda77b3a92022-12-21T21:18:20ZengBMCBMC Cancer1471-24072010-07-0110135910.1186/1471-2407-10-359Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigenXing XiaofangQu LikeLu AipingDong BinLiu CaiyunMeng LinWu JianEric Shi YShou Chengchao<p>Abstract</p> <p>Background</p> <p>Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this study, we investigated the prognostic potential of SNCG in colon cancer particularly in the patients with normal carcinoembryonic antigen (CEA) levels.</p> <p>Methods</p> <p>SNCG levels were assessed immunohistochemically in cancer tissues from 229 colon adenocarcinoma patients with a mean follow-up of 44 months. Correlations between SNCG levels and clinicopathologic features, preoperative serum CEA level, and clinical outcome were analyzed statistically using SPSS.</p> <p>Results</p> <p>SNCG levels in colon adenocarcinoma were closely associated with intravascular embolus and tumor recurrence but independent of preoperative serum CEA levels. SNCG expression was an independent prognostic factor of a shorter disease-free survival (DFS) and overall survival (OS) (<it>P </it>< 0.0001). Multivariate analysis revealed that both tissue SNCG and serum CEA were independent prognostic factors of DFS (<it>P </it>= 0.001, <0.0001, respectively) for 170 patients with colon adenocarcinomas. Importantly, SNCG remained a prognostic determinant of DFS and OS (<it>P </it>= 0.001, 0.002) for 97 patients with normal preoperative serum CEA level.</p> <p>Conclusions</p> <p>Our results suggest for the first time that SNCG is a new independent predicator for poor prognosis in patients with colon adenocarcinoma, including those with normal CEA levels. Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma.</p>http://www.biomedcentral.com/1471-2407/10/359 |
| spellingShingle | Xing Xiaofang Qu Like Lu Aiping Dong Bin Liu Caiyun Meng Lin Wu Jian Eric Shi Y Shou Chengchao Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen BMC Cancer |
| title | Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| title_full | Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| title_fullStr | Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| title_full_unstemmed | Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| title_short | Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| title_sort | synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen |
| url | http://www.biomedcentral.com/1471-2407/10/359 |
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