Transient Global Amnesia in a Patient with Postherpetic Neuralgia
Transient global amnesia (TGA) is a clinical syndrome of reversible anterograde amnesia that occurs in the middle-aged and elderly individuals. The etiology is obscure, and many underlying factors have been reported. We describe an 83-year-old man with postherpetic neuralgia (PHN) for which he recei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Society of Tokyo Women's Medical University
2018-05-01
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| Series: | Tokyo Women's Medical University Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2017004/_pdf/-char/en |
| _version_ | 1818380512012533760 |
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| author | Yukiko MUKUBO Miwako KAWAMATA Makiko KOMORI |
| author_facet | Yukiko MUKUBO Miwako KAWAMATA Makiko KOMORI |
| author_sort | Yukiko MUKUBO |
| collection | DOAJ |
| description | Transient global amnesia (TGA) is a clinical syndrome of reversible anterograde amnesia that occurs in the middle-aged and elderly individuals. The etiology is obscure, and many underlying factors have been reported. We describe an 83-year-old man with postherpetic neuralgia (PHN) for which he received pregabalin, fentanyl, and a serotonin-norepinephrine reuptake inhibitor (SNRI). Pain intensity on a numeral rating scale (NRS) was 8/10. He had no history of vascular disease or epilepsy.On November 28th 20XX he visited our hospital and underwent intercostal nerve block with phototherapy as usual. He was slightly feverish and had a body temperature of 37.8°C with no other symptoms. After 15 minutes rest, he left our hospital and tried to return to his home, but he was unsure which train to take. About 4 hours later, he suddenly knew where he was and got back to his home uneventfully. He had been amnetic for several hours. Two weeks later, he was referred to a neurologist, and the episode was diagnosed as TGA. Brain magnetic resonance imaging (MRI) showed non-specific cerebral atrophy with signs of aging at that point. Differential diagnoses include ischemia, migraine, epileptic seizures, and thromboembolic cerebrovascular disease. The cause of TGA remains controversial. However, drugs such as GABAergic drugs, SNRIs, and opioids are known to have effects on cognitive function. Polypharmacy can result in substantial drug-drug interactions, especially in elderly patients. The trigger of this episode in our patient is unclear, but multiple analgesics might have been a causal factor of his symptoms of TGA. |
| first_indexed | 2024-12-14T02:19:51Z |
| format | Article |
| id | doaj.art-085a8c3245cd47f99e6892c3a443f10b |
| institution | Directory Open Access Journal |
| issn | 2432-6186 |
| language | English |
| last_indexed | 2024-12-14T02:19:51Z |
| publishDate | 2018-05-01 |
| publisher | Society of Tokyo Women's Medical University |
| record_format | Article |
| series | Tokyo Women's Medical University Journal |
| spelling | doaj.art-085a8c3245cd47f99e6892c3a443f10b2022-12-21T23:20:32ZengSociety of Tokyo Women's Medical UniversityTokyo Women's Medical University Journal2432-61862018-05-0120373910.24488/twmuj.2017004twmujTransient Global Amnesia in a Patient with Postherpetic NeuralgiaYukiko MUKUBO0Miwako KAWAMATA1Makiko KOMORI2Department of Anesthesiology, Nadogaya HopspitalDepartment of Anesthesiology, Tokyo Women's Medical University Medical Center EastDepartment of Anesthesiology, Tokyo Women's Medical University Medical Center EastTransient global amnesia (TGA) is a clinical syndrome of reversible anterograde amnesia that occurs in the middle-aged and elderly individuals. The etiology is obscure, and many underlying factors have been reported. We describe an 83-year-old man with postherpetic neuralgia (PHN) for which he received pregabalin, fentanyl, and a serotonin-norepinephrine reuptake inhibitor (SNRI). Pain intensity on a numeral rating scale (NRS) was 8/10. He had no history of vascular disease or epilepsy.On November 28th 20XX he visited our hospital and underwent intercostal nerve block with phototherapy as usual. He was slightly feverish and had a body temperature of 37.8°C with no other symptoms. After 15 minutes rest, he left our hospital and tried to return to his home, but he was unsure which train to take. About 4 hours later, he suddenly knew where he was and got back to his home uneventfully. He had been amnetic for several hours. Two weeks later, he was referred to a neurologist, and the episode was diagnosed as TGA. Brain magnetic resonance imaging (MRI) showed non-specific cerebral atrophy with signs of aging at that point. Differential diagnoses include ischemia, migraine, epileptic seizures, and thromboembolic cerebrovascular disease. The cause of TGA remains controversial. However, drugs such as GABAergic drugs, SNRIs, and opioids are known to have effects on cognitive function. Polypharmacy can result in substantial drug-drug interactions, especially in elderly patients. The trigger of this episode in our patient is unclear, but multiple analgesics might have been a causal factor of his symptoms of TGA.https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2017004/_pdf/-char/englobal amnesiapostherpetic neuralgiapolypharmacy |
| spellingShingle | Yukiko MUKUBO Miwako KAWAMATA Makiko KOMORI Transient Global Amnesia in a Patient with Postherpetic Neuralgia Tokyo Women's Medical University Journal global amnesia postherpetic neuralgia polypharmacy |
| title | Transient Global Amnesia in a Patient with Postherpetic Neuralgia |
| title_full | Transient Global Amnesia in a Patient with Postherpetic Neuralgia |
| title_fullStr | Transient Global Amnesia in a Patient with Postherpetic Neuralgia |
| title_full_unstemmed | Transient Global Amnesia in a Patient with Postherpetic Neuralgia |
| title_short | Transient Global Amnesia in a Patient with Postherpetic Neuralgia |
| title_sort | transient global amnesia in a patient with postherpetic neuralgia |
| topic | global amnesia postherpetic neuralgia polypharmacy |
| url | https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2017004/_pdf/-char/en |
| work_keys_str_mv | AT yukikomukubo transientglobalamnesiainapatientwithpostherpeticneuralgia AT miwakokawamata transientglobalamnesiainapatientwithpostherpeticneuralgia AT makikokomori transientglobalamnesiainapatientwithpostherpeticneuralgia |