Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity
This report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented i...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/12/1/19 |
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| author | Alexey A. Makarov Lilya U. Dzhemileva Elina Kh. Makarova Usein M. Dzhemilev |
| author_facet | Alexey A. Makarov Lilya U. Dzhemileva Elina Kh. Makarova Usein M. Dzhemilev |
| author_sort | Alexey A. Makarov |
| collection | DOAJ |
| description | This report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in this report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis. |
| first_indexed | 2024-03-11T02:37:29Z |
| format | Article |
| id | doaj.art-085db8a54d354f23ac7191395da8c391 |
| institution | Directory Open Access Journal |
| issn | 2673-4583 |
| language | English |
| last_indexed | 2024-03-11T02:37:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj.art-085db8a54d354f23ac7191395da8c3912023-11-18T09:47:50ZengMDPI AGChemistry Proceedings2673-45832022-11-011211910.3390/ecsoc-26-13524Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic ActivityAlexey A. Makarov0Lilya U. Dzhemileva1Elina Kh. Makarova2Usein M. Dzhemilev3Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospect Oktyabrya 141, 450075 Ufa, RussiaN. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky Prospect, 47, 119991 Moscow, RussiaInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospect Oktyabrya 141, 450075 Ufa, RussiaN. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky Prospect, 47, 119991 Moscow, RussiaThis report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in this report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis.https://www.mdpi.com/2673-4583/12/1/19Lembehynes A–C1Z,5Z-dienescross-cyclomagnesiationanti-cancerneuritogenic activity |
| spellingShingle | Alexey A. Makarov Lilya U. Dzhemileva Elina Kh. Makarova Usein M. Dzhemilev Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity Chemistry Proceedings Lembehynes A–C 1Z,5Z-dienes cross-cyclomagnesiation anti-cancer neuritogenic activity |
| title | Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity |
| title_full | Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity |
| title_fullStr | Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity |
| title_full_unstemmed | Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity |
| title_short | Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity |
| title_sort | development of new effective methods for the synthesis of lembehynes a c exhibiting cytotoxic and neuritogenic activity |
| topic | Lembehynes A–C 1Z,5Z-dienes cross-cyclomagnesiation anti-cancer neuritogenic activity |
| url | https://www.mdpi.com/2673-4583/12/1/19 |
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