Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations
In published research that includes genome-wide association studies and meta-analyses, the phosphodiesterase 4D (PDE4D) rs966221 variant has been identified as a risk factor in ischemic stroke (IS) in the Caucasian population. Several studies have investigated the relationship between rs966221 and I...
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MDPI AG
2023-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/7/1038 |
| _version_ | 1827733579772198912 |
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| author | Chunyang Wang Fenghe Zhang Xiaojing Zhang Chao Zhang He Li |
| author_facet | Chunyang Wang Fenghe Zhang Xiaojing Zhang Chao Zhang He Li |
| author_sort | Chunyang Wang |
| collection | DOAJ |
| description | In published research that includes genome-wide association studies and meta-analyses, the phosphodiesterase 4D (PDE4D) rs966221 variant has been identified as a risk factor in ischemic stroke (IS) in the Caucasian population. Several studies have investigated the relationship between rs966221 and IS susceptibility in Chinese populations over the years but have not provided consistently conclusive results. Therefore, our team performed a new meta-analysis of 5973 IS patients and 6204 controls from qualified studies. We observed no significant link between the PDE4D rs966221 variant and IS in any of the regional Chinese populations. Thus, we performed a subgroup analysis by the geographical distribution of China. Notably, significant associations were observed between rs96622 and the susceptibility of IS in the Northeast Chinese populations (<i>p</i> = 1.00 × 10<sup>−4</sup>, odds ratio = 1.28, and 95% confidence interval = 1.13–1.44, I<sup>2</sup> = 0%). However, rs966221 was not found to be correlated with IS risk in the populations of North, Central, South, and East China. Our meta-analysis demonstrated that the PDE4D rs966221 variant is significantly associated with IS risk in some regional Chinese populations. |
| first_indexed | 2024-03-11T01:14:13Z |
| format | Article |
| id | doaj.art-085ec8b2149843539cd9ce278e6ecc62 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T01:14:13Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-085ec8b2149843539cd9ce278e6ecc622023-11-18T18:34:28ZengMDPI AGBrain Sciences2076-34252023-07-01137103810.3390/brainsci13071038Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese PopulationsChunyang Wang0Fenghe Zhang1Xiaojing Zhang2Chao Zhang3He Li4Department of Scientific Research, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Neurology and Institute of Neuroimmunology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaClinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 301700, ChinaDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaIn published research that includes genome-wide association studies and meta-analyses, the phosphodiesterase 4D (PDE4D) rs966221 variant has been identified as a risk factor in ischemic stroke (IS) in the Caucasian population. Several studies have investigated the relationship between rs966221 and IS susceptibility in Chinese populations over the years but have not provided consistently conclusive results. Therefore, our team performed a new meta-analysis of 5973 IS patients and 6204 controls from qualified studies. We observed no significant link between the PDE4D rs966221 variant and IS in any of the regional Chinese populations. Thus, we performed a subgroup analysis by the geographical distribution of China. Notably, significant associations were observed between rs96622 and the susceptibility of IS in the Northeast Chinese populations (<i>p</i> = 1.00 × 10<sup>−4</sup>, odds ratio = 1.28, and 95% confidence interval = 1.13–1.44, I<sup>2</sup> = 0%). However, rs966221 was not found to be correlated with IS risk in the populations of North, Central, South, and East China. Our meta-analysis demonstrated that the PDE4D rs966221 variant is significantly associated with IS risk in some regional Chinese populations.https://www.mdpi.com/2076-3425/13/7/1038ischemic strokegenome-wide association studypde4drs966221Chinese population |
| spellingShingle | Chunyang Wang Fenghe Zhang Xiaojing Zhang Chao Zhang He Li Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations Brain Sciences ischemic stroke genome-wide association study pde4d rs966221 Chinese population |
| title | Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations |
| title_full | Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations |
| title_fullStr | Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations |
| title_full_unstemmed | Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations |
| title_short | Association between PDE4D rs966221 and the Risk of Ischemic Stroke in Regional Chinese Populations |
| title_sort | association between pde4d rs966221 and the risk of ischemic stroke in regional chinese populations |
| topic | ischemic stroke genome-wide association study pde4d rs966221 Chinese population |
| url | https://www.mdpi.com/2076-3425/13/7/1038 |
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