Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors

Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors

The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. However, cellular immunity is essential for long-term viral control and protection from disease severity. To understand T-cell immunity in the absence of antibody generation we foc...

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Bibliographic Details
Main Authors: Athina Kilpeläinen, Esther Jimenez-Moyano, Oscar Blanch-Lombarte, Dan Ouchi, Ruth Peña, Bibiana Quirant-Sanchez, Raul Perez-Caballero, Anna Chamorro, Ignacio Blanco, Eva Martínez-Caceres, Roger Paredes, Lourdes Mateu, Jorge Carrillo, Julià Blanco, Christian Brander, Marta Massanella, Bonaventura Clotet, Julia G. Prado
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
non-seroconvertor
cellular immunity
T cell subsets
immune activation
function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.815041/full

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