Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder
Abstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced osci...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-96209-7 |
| _version_ | 1818422513404739584 |
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| author | Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert |
| author_facet | Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert |
| author_sort | Paul A. Schauer |
| collection | DOAJ |
| description | Abstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences. |
| first_indexed | 2024-12-14T13:27:27Z |
| format | Article |
| id | doaj.art-0860e531bc0b461da5b56d12d4593458 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:27:27Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0860e531bc0b461da5b56d12d45934582022-12-21T22:59:47ZengNature PortfolioScientific Reports2045-23222021-08-0111111010.1038/s41598-021-96209-7Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorderPaul A. Schauer0Jonas Rauh1Sarah V. Biedermann2Moritz Haaf3Saskia Steinmann4Gregor Leicht5Christoph Mulert6Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfDepartment of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, Center of Psychosocial Medicine, University Medical Center Hamburg-EppendorfAbstract Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences.https://doi.org/10.1038/s41598-021-96209-7 |
| spellingShingle | Paul A. Schauer Jonas Rauh Sarah V. Biedermann Moritz Haaf Saskia Steinmann Gregor Leicht Christoph Mulert Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder Scientific Reports |
| title | Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder |
| title_full | Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder |
| title_fullStr | Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder |
| title_full_unstemmed | Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder |
| title_short | Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder |
| title_sort | simultaneous eeg fmri reveals theta network alterations during reward feedback processing in borderline personality disorder |
| url | https://doi.org/10.1038/s41598-021-96209-7 |
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