Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
7-MEGA<sup>TM</sup> is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocate...
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2072-6643/16/2/212 |
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| author | Hyun Kyung Sung Tae Jeong Kim Hyung Mook Kim Sang Jun Youn Yong Choi Na Young Lee Hyun Jeong Oh Hyuck Se Kwon Seon Mi Shin |
| author_facet | Hyun Kyung Sung Tae Jeong Kim Hyung Mook Kim Sang Jun Youn Yong Choi Na Young Lee Hyun Jeong Oh Hyuck Se Kwon Seon Mi Shin |
| author_sort | Hyun Kyung Sung |
| collection | DOAJ |
| description | 7-MEGA<sup>TM</sup> is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocated to the intervention (<i>N</i> = 50) or placebo group (<i>N</i> = 51). Each participant was advised to take either 500 mg of 7-MEGA<sup>TM</sup> or a placebo twice daily for 12 weeks. The primary outcomes were the degree of improvement in wrinkles and the degree of moisture filling after consumption for 12 weeks compared to baseline. The secondary outcomes were improvement in skin wrinkles; moisture changes at 4 and 8 weeks from baseline; changes in transdermal water loss, skin elasticity, the melanin index, the erythema index, and the Global Photo Damage Score. We found a significant improvement in skin wrinkles and elasticity at 12 weeks in the 7-MEGA<sup>TM</sup>-consuming group compared to that in the placebo group; skin moisture, elasticity, and the melanin index were also improved. No supplement-related adverse reactions were observed and 7-MEGA<sup>TM</sup> was identified as safe. 7-MEGA<sup>TM</sup> was effective for human skin function in terms of wrinkles, moisture, elasticity, and melanin production and may be useful as a skin nutritional supplement. |
| first_indexed | 2024-03-08T09:48:22Z |
| format | Article |
| id | doaj.art-0864ad5edbd549108ecdeaec28745f9b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T09:48:22Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0864ad5edbd549108ecdeaec28745f9b2024-01-29T14:09:45ZengMDPI AGNutrients2072-66432024-01-0116221210.3390/nu16020212Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical TrialHyun Kyung Sung0Tae Jeong Kim1Hyung Mook Kim2Sang Jun Youn3Yong Choi4Na Young Lee5Hyun Jeong Oh6Hyuck Se Kwon7Seon Mi Shin8Global Cosmeceutical Center, Semyung University, Cheongju 28161, Republic of KoreaDepartment of Pediatrics, Semyung University Chungju Korean Medicine Hospital, Chungju 27429, Republic of KoreaGlobal Cosmeceutical Center, Semyung University, Cheongju 28161, Republic of KoreaRnBS Corporation, Seoul 06032, Republic of KoreaRnBS Corporation, Seoul 06032, Republic of KoreaR&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of KoreaR&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of KoreaR&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of KoreaDepartment of Internal Medicine, College of Korean Medicine, Semyung University, Jecheon 27136, Republic of Korea7-MEGA<sup>TM</sup> is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocated to the intervention (<i>N</i> = 50) or placebo group (<i>N</i> = 51). Each participant was advised to take either 500 mg of 7-MEGA<sup>TM</sup> or a placebo twice daily for 12 weeks. The primary outcomes were the degree of improvement in wrinkles and the degree of moisture filling after consumption for 12 weeks compared to baseline. The secondary outcomes were improvement in skin wrinkles; moisture changes at 4 and 8 weeks from baseline; changes in transdermal water loss, skin elasticity, the melanin index, the erythema index, and the Global Photo Damage Score. We found a significant improvement in skin wrinkles and elasticity at 12 weeks in the 7-MEGA<sup>TM</sup>-consuming group compared to that in the placebo group; skin moisture, elasticity, and the melanin index were also improved. No supplement-related adverse reactions were observed and 7-MEGA<sup>TM</sup> was identified as safe. 7-MEGA<sup>TM</sup> was effective for human skin function in terms of wrinkles, moisture, elasticity, and melanin production and may be useful as a skin nutritional supplement.https://www.mdpi.com/2072-6643/16/2/212omega-77-MEGA<sup>TM</sup>randomized controlled trialskin nutritional supplementsskin aging |
| spellingShingle | Hyun Kyung Sung Tae Jeong Kim Hyung Mook Kim Sang Jun Youn Yong Choi Na Young Lee Hyun Jeong Oh Hyuck Se Kwon Seon Mi Shin Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial Nutrients omega-7 7-MEGA<sup>TM</sup> randomized controlled trial skin nutritional supplements skin aging |
| title | Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| title_full | Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| title_fullStr | Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| title_full_unstemmed | Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| title_short | Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGA<sup>TM</sup>: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| title_sort | anti wrinkle and skin moisture efficacy of 7 mega sup tm sup a randomized double blind placebo comparative clinical trial |
| topic | omega-7 7-MEGA<sup>TM</sup> randomized controlled trial skin nutritional supplements skin aging |
| url | https://www.mdpi.com/2072-6643/16/2/212 |
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