Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease
Intestinal microbiota dysbiosis has been described in inflammatory bowel disease (IBD), but data from China are limited. In this study, we performed molecular analysis of the fecal microbial community from 20 healthy Chinese subjects and 25 patients with Crohn’s disease (CD), and evaluated associati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-11-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756284820971202 |
| _version_ | 1819295401888448512 |
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| author | Xinyun Qiu Xiaojing Zhao Xiufang Cui Xiaqiong Mao Nana Tang Chunhua Jiao Di Wang Yue Zhang Ziping Ye Hongjie Zhang |
| author_facet | Xinyun Qiu Xiaojing Zhao Xiufang Cui Xiaqiong Mao Nana Tang Chunhua Jiao Di Wang Yue Zhang Ziping Ye Hongjie Zhang |
| author_sort | Xinyun Qiu |
| collection | DOAJ |
| description | Intestinal microbiota dysbiosis has been described in inflammatory bowel disease (IBD), but data from China are limited. In this study, we performed molecular analysis of the fecal microbial community from 20 healthy Chinese subjects and 25 patients with Crohn’s disease (CD), and evaluated associations with bacterial and fungal compositions. Decreased richness and diversity of bacterial composition was observed in the CD group compared with healthy (H) subjects. Significant structural differences in bacterial (but not fungal) composition among healthy controls and CD patients were found. A reduction in Firmicutes and Actinobacteria abundance, and overrepresentation of Proteobacteria were observed in the CD patients compared with the H group. The Escherichia-Shigella genus was overrepresented in the CD group, whereas Faecalibacterium, Gemmiger, Bifidobacterium, Romboutsia, Ruminococcus, Roseburia , and Fusicatenibacter abundance were decreased in the CD group compared with H subjects. Differences in fungal microbiota between the H and CD groups were observed at the genus rather than at the phylum level. The Candida genus was overrepresented in the CD (active disease) group compared with the H group, whereas no difference between CD (remission) and H groups was observed. Aspergillus, unclassified_Sordariomycetes , and Penicillium genera had greater representation in the H subjects compared with the CD group. Bacterial and fungal intra- and inter-kingdom correlations were observed between the H and CD groups. Therefore, fecal bacterial and fungal microbiome communities differed considerably between H and CD patients, and between Chinese and Western populations. The role of gut microbiota in homeostasis and in gastrointestinal disorders should be investigated further. |
| first_indexed | 2024-12-24T04:41:38Z |
| format | Article |
| id | doaj.art-0866989ec68e480b947eeb525a81dfc6 |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-12-24T04:41:38Z |
| publishDate | 2020-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-0866989ec68e480b947eeb525a81dfc62022-12-21T17:14:48ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482020-11-011310.1177/1756284820971202Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s diseaseXinyun QiuXiaojing ZhaoXiufang CuiXiaqiong MaoNana TangChunhua JiaoDi WangYue ZhangZiping YeHongjie ZhangIntestinal microbiota dysbiosis has been described in inflammatory bowel disease (IBD), but data from China are limited. In this study, we performed molecular analysis of the fecal microbial community from 20 healthy Chinese subjects and 25 patients with Crohn’s disease (CD), and evaluated associations with bacterial and fungal compositions. Decreased richness and diversity of bacterial composition was observed in the CD group compared with healthy (H) subjects. Significant structural differences in bacterial (but not fungal) composition among healthy controls and CD patients were found. A reduction in Firmicutes and Actinobacteria abundance, and overrepresentation of Proteobacteria were observed in the CD patients compared with the H group. The Escherichia-Shigella genus was overrepresented in the CD group, whereas Faecalibacterium, Gemmiger, Bifidobacterium, Romboutsia, Ruminococcus, Roseburia , and Fusicatenibacter abundance were decreased in the CD group compared with H subjects. Differences in fungal microbiota between the H and CD groups were observed at the genus rather than at the phylum level. The Candida genus was overrepresented in the CD (active disease) group compared with the H group, whereas no difference between CD (remission) and H groups was observed. Aspergillus, unclassified_Sordariomycetes , and Penicillium genera had greater representation in the H subjects compared with the CD group. Bacterial and fungal intra- and inter-kingdom correlations were observed between the H and CD groups. Therefore, fecal bacterial and fungal microbiome communities differed considerably between H and CD patients, and between Chinese and Western populations. The role of gut microbiota in homeostasis and in gastrointestinal disorders should be investigated further.https://doi.org/10.1177/1756284820971202 |
| spellingShingle | Xinyun Qiu Xiaojing Zhao Xiufang Cui Xiaqiong Mao Nana Tang Chunhua Jiao Di Wang Yue Zhang Ziping Ye Hongjie Zhang Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease Therapeutic Advances in Gastroenterology |
| title | Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease |
| title_full | Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease |
| title_fullStr | Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease |
| title_full_unstemmed | Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease |
| title_short | Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn’s disease |
| title_sort | characterization of fungal and bacterial dysbiosis in young adult chinese patients with crohn s disease |
| url | https://doi.org/10.1177/1756284820971202 |
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