External Basic Hyperthermia Devices for Preclinical Studies in Small Animals
Preclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Rep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/18/4628 |
| _version_ | 1797519942921224192 |
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| author | Marjolein I. Priester Sergio Curto Gerard C. van Rhoon Timo L. M. ten Hagen |
| author_facet | Marjolein I. Priester Sergio Curto Gerard C. van Rhoon Timo L. M. ten Hagen |
| author_sort | Marjolein I. Priester |
| collection | DOAJ |
| description | Preclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Reproducibility of methods in and between research groups on the same techniques is crucial to have a better prediction of the clinical outcome and to improve new treatment strategies (for instance with heat-sensitive nanoparticles). Here we provide a preclinically oriented review on the use and applicability of basic hyperthermia systems available for solid tumor thermal treatment in small animals. The complexity of these techniques ranges from a simple, low-cost water bath approach, irradiation with light or lasers, to advanced ultrasound and capacitive heating devices. |
| first_indexed | 2024-03-10T07:49:56Z |
| format | Article |
| id | doaj.art-08689fe0a0754576bd6cfa3f17a72b74 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:49:56Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-08689fe0a0754576bd6cfa3f17a72b742023-11-22T12:18:08ZengMDPI AGCancers2072-66942021-09-011318462810.3390/cancers13184628External Basic Hyperthermia Devices for Preclinical Studies in Small AnimalsMarjolein I. Priester0Sergio Curto1Gerard C. van Rhoon2Timo L. M. ten Hagen3Laboratory of Experimental Oncology, Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsLaboratory of Experimental Oncology, Department of Pathology, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsPreclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Reproducibility of methods in and between research groups on the same techniques is crucial to have a better prediction of the clinical outcome and to improve new treatment strategies (for instance with heat-sensitive nanoparticles). Here we provide a preclinically oriented review on the use and applicability of basic hyperthermia systems available for solid tumor thermal treatment in small animals. The complexity of these techniques ranges from a simple, low-cost water bath approach, irradiation with light or lasers, to advanced ultrasound and capacitive heating devices.https://www.mdpi.com/2072-6694/13/18/4628hyperthermiapreclinical hyperthermiasmall animalsstandardizationmultimodal therapy |
| spellingShingle | Marjolein I. Priester Sergio Curto Gerard C. van Rhoon Timo L. M. ten Hagen External Basic Hyperthermia Devices for Preclinical Studies in Small Animals Cancers hyperthermia preclinical hyperthermia small animals standardization multimodal therapy |
| title | External Basic Hyperthermia Devices for Preclinical Studies in Small Animals |
| title_full | External Basic Hyperthermia Devices for Preclinical Studies in Small Animals |
| title_fullStr | External Basic Hyperthermia Devices for Preclinical Studies in Small Animals |
| title_full_unstemmed | External Basic Hyperthermia Devices for Preclinical Studies in Small Animals |
| title_short | External Basic Hyperthermia Devices for Preclinical Studies in Small Animals |
| title_sort | external basic hyperthermia devices for preclinical studies in small animals |
| topic | hyperthermia preclinical hyperthermia small animals standardization multimodal therapy |
| url | https://www.mdpi.com/2072-6694/13/18/4628 |
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