An international analysis of stem cell research in intervertebral disc degeneration
Stem cell therapy has been increasingly investigated as a promising strategy for intervertebral disc degeneration (IDD). However, no international analysis of stem cell research has yet been conducted. This study aimed to analyze the major characteristics of published reports of stem cell use for ID...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123000302 |
| _version_ | 1797897274082197504 |
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| author | Zhiwei Jia Donghua Liu Jiao Xu Qiang Wang Longyu Zhang Shi Yin Bo Qian Xingxuan Li Yaohong Wu Yan Zhang Wei Li Tianlin Wen |
| author_facet | Zhiwei Jia Donghua Liu Jiao Xu Qiang Wang Longyu Zhang Shi Yin Bo Qian Xingxuan Li Yaohong Wu Yan Zhang Wei Li Tianlin Wen |
| author_sort | Zhiwei Jia |
| collection | DOAJ |
| description | Stem cell therapy has been increasingly investigated as a promising strategy for intervertebral disc degeneration (IDD). However, no international analysis of stem cell research has yet been conducted. This study aimed to analyze the major characteristics of published reports of stem cell use for IDD and to present a global insight into stem cell research. The study period spanned from the inception of the Web of Science database to 2021. A search strategy using specific keywords was implemented to retrieve relevant publications. The numbers of documents, citations, countries, journals, article types, and stem cell types were evaluated. A total of 1170 papers were retrieved. The analysis showed a significant increase in the number of papers over time (p < 0.001). High-income economies accounted for the majority of papers (758, 64.79 %). China produced the most articles (378, 32.31 %), followed by the United States (259, 22.14 %), Switzerland (69, 5.90 %), United Kingdom (54, 4.62 %), and Japan (47, 4.02 %). The United States ranked first in terms of the number of citations (10,346), followed by China (9177) and Japan (3522). Japan ranked first in terms of the number of citations per paper (74.94), followed by United Kingdom (58.54) and Canada (53.74). When standardized by population, Switzerland ranked first, followed by Ireland and Sweden. When gross domestic product was considered, Switzerland ranked first, followed by Portugal and Ireland. The number of papers was positively correlated with gross domestic product (p < 0.001, r = 0.673); however, there was no significant correlation with population (p = 0.062, r = 0.294). Mesenchymal stem cells were the most investigated stem cells, followed by nucleus pulposus-derived stem cells and adipose-derived stem cells. A sharp increase in stem cell research was observed in the field of IDD. China produced the most, although several European countries were more productive relative to their populations and economies. |
| first_indexed | 2024-04-10T07:54:54Z |
| format | Article |
| id | doaj.art-0868a1a2746a4f198b58fb02e86cf2dc |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-10T07:54:54Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-0868a1a2746a4f198b58fb02e86cf2dc2023-02-23T04:30:57ZengElsevierStem Cell Research1873-50612023-03-0167103044An international analysis of stem cell research in intervertebral disc degenerationZhiwei Jia0Donghua Liu1Jiao Xu2Qiang Wang3Longyu Zhang4Shi Yin5Bo Qian6Xingxuan Li7Yaohong Wu8Yan Zhang9Wei Li10Tianlin Wen11Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Spine Surgery, Ganzhou People’s Hospital, Ganzhou, China; Corresponding authors.Department of TCM Orthopedics, Sixth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing, China; Corresponding authors.Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China; Corresponding authors.Stem cell therapy has been increasingly investigated as a promising strategy for intervertebral disc degeneration (IDD). However, no international analysis of stem cell research has yet been conducted. This study aimed to analyze the major characteristics of published reports of stem cell use for IDD and to present a global insight into stem cell research. The study period spanned from the inception of the Web of Science database to 2021. A search strategy using specific keywords was implemented to retrieve relevant publications. The numbers of documents, citations, countries, journals, article types, and stem cell types were evaluated. A total of 1170 papers were retrieved. The analysis showed a significant increase in the number of papers over time (p < 0.001). High-income economies accounted for the majority of papers (758, 64.79 %). China produced the most articles (378, 32.31 %), followed by the United States (259, 22.14 %), Switzerland (69, 5.90 %), United Kingdom (54, 4.62 %), and Japan (47, 4.02 %). The United States ranked first in terms of the number of citations (10,346), followed by China (9177) and Japan (3522). Japan ranked first in terms of the number of citations per paper (74.94), followed by United Kingdom (58.54) and Canada (53.74). When standardized by population, Switzerland ranked first, followed by Ireland and Sweden. When gross domestic product was considered, Switzerland ranked first, followed by Portugal and Ireland. The number of papers was positively correlated with gross domestic product (p < 0.001, r = 0.673); however, there was no significant correlation with population (p = 0.062, r = 0.294). Mesenchymal stem cells were the most investigated stem cells, followed by nucleus pulposus-derived stem cells and adipose-derived stem cells. A sharp increase in stem cell research was observed in the field of IDD. China produced the most, although several European countries were more productive relative to their populations and economies.http://www.sciencedirect.com/science/article/pii/S1873506123000302 |
| spellingShingle | Zhiwei Jia Donghua Liu Jiao Xu Qiang Wang Longyu Zhang Shi Yin Bo Qian Xingxuan Li Yaohong Wu Yan Zhang Wei Li Tianlin Wen An international analysis of stem cell research in intervertebral disc degeneration Stem Cell Research |
| title | An international analysis of stem cell research in intervertebral disc degeneration |
| title_full | An international analysis of stem cell research in intervertebral disc degeneration |
| title_fullStr | An international analysis of stem cell research in intervertebral disc degeneration |
| title_full_unstemmed | An international analysis of stem cell research in intervertebral disc degeneration |
| title_short | An international analysis of stem cell research in intervertebral disc degeneration |
| title_sort | international analysis of stem cell research in intervertebral disc degeneration |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123000302 |
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